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1-Meet the Scientist: Watch interview with Dr Frederick Hayden who is an expert in antivirals to influenza. What are the targets and mechanisms of action of antiviral drugs to influenza? Why are there so few antivirals to influenza available? What are the problems with treating influenza with antivirals?
2-Drug resistance is a major obstacle for the development of antiviral therapies. How does resistance arise and why is it such a significant problem? Why do multi-drug combinations therapies help alleviate this problem? Give examples with a specific virus.
3-The first drug to be rationally developed to treat a viral disease was that of acyclovir for herpes virus infections. Read the first person account of the discovery of acyclovir by Nobel laureate Gertrude Elion. How does acyclovir inhibit a herpes virus infection? Why is it specific for virally infected cells, but not normal cells?
4-Meet the Scientist: Watch this short interview about how influenza vaccines are produced with Dr Derek Smith at the 2010 Interscience Conference on Antibacterial Agents and Chemotherapy (ICAAC). Why is a new vaccine required for influenza each year? What is the Global Influenza Surveillance Network and how do they select a new vaccine each year? What type of vaccine is the seasonal influenza vaccine?
5-A major problem with vaccinating populations against Influenza A viruses is that a new vaccine must be developed each year. In the last few years, ideas have been proposed for making "Universal Influenza Vaccines" that would provide universal immunity against all or most strains of influenza A. The lab of Peter Palese at the Mt Sinai Medical Center has recently proposed a method for generating a universal vaccine using a "headless HA." Read the original paper and/or listen to the short interview with Peter Palese. What is his concept for generating a universal influenza vaccine? Do you think this is a good idea? Why or why not? Could this concept be applied to develop vaccines for other viruses such as HIV?
A mutant prostist is found in which some mitochondria lack an inner mitochondrial membrane. Which pathways would be completely disrupted in these mitochondria.
What is the genotypic and phenotypic ratio in the offspring produced by the cross AABb x Aabb if A is green colour, a - yellow; B- tall plants. b -short plant? Suppose complete dominance for the trait. Describe results of the cross using branching di..
Clarify the effects of the ecb infestation you used. Were all corn varieties evenly effective at controlling the ecb? How do you know.
Most biologists believe that immune system's defense against infections largely rests on its ability to distinguish self molecules from nonself molecules.
Explain plant life, animal life, and geology of the ecosystem in Utah. What populations and communities are present? How dependant is your community on this ecosystem? What are the preventive factors of the ecosystem.
On the coding strand above, indicate where you would expect FRP to bind to the DNA. In one sentence, describe why the decision makes sense.
Determine which of these would synthesize the enzymes for Histidine synthesis
Fats in the diet have satiety value they stay in stomach longer so we feel fuller longer. Fats provide protective coatings on the body surfaces to help prevent dehydration. Lipids - 2 what are the main categories of lipids found in humans.
A small, impermeable membrane is placed between the anchor cell and the other vulva precursor cells in a larva of C. elegans. What would you expect the result to be.
Which organelle generates oxygen? Which organelle consumes oxygen? Explain why are viruses not considered to be living?
How does the net amount of energy released during the breakdown of sucrose compare between spontaneous reactions and catalyzed by sucrase.
In the movie, Lost in Space, spider-like creatures attacked members of the Robinson family as they explored an abandoned spaceship. Maureen (the mom) scans the creatures and reports that the spiders are silicon-based life-forms.
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