Loss-of-function mutation in mitochondrial gene

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MERRF is caused by heteroplasmy for a loss-of-function mutation in a mitochondrial gene. A set of identical twins was reported in Australia where one twin had symptoms of MERRF, and the other did not. Choose all of the statements that could explain this phenomenon. Check All That Apply One twin had a new mutation in a mtDNA early in development. One twin had a new mutation in a mtDNA early in development. Each twin originally inherited different fractions of mutant mtDNAs. Each twin originally inherited different fractions of mutant mtDNAs. One twin inherited its mtDNA from its father, and the other twin inherited its mtDNA from its mother. One twin inherited its mtDNA from its father, and the other twin inherited its mtDNA from its mother.

Reference no: EM134019279

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