Hypothesize a molecular mechanism by nucleotide change

Assignment Help Biology
Reference no: EM1394951

Smilin is a (hypothetical) protein that causes people to be happy. It is inactive in many chronically unhappy people. The mRNA isolated from a number of different unhappy persons in the same family was found to lack an internal stretch of 173-nucleotides that are present in the Smilin mRNA isolated from a control group of generally happy people. The DNA sequences of the Smilin genes from the happy and unhappy persons were determined and compared. They differed by just one nucleotide change---and no nucleotides were deleted. Moreover, the change was found in an intron.
Can you hypothesize a molecular mechanism by which a single nucleotide change in a gene could cause the observed internal deletion in the mRNA? Be sure to include a comparison of the mechanism that is involved between what happens in the normal and mutant transcript.
What consequences for the Smilin protein would result from removing a 173-nucleotide-long internal stretch from the coding region of the Smiling mRNA?

Reference no: EM1394951

Questions Cloud

Using a liquid sample of na : Using a liquid sample of Na that has a molar heat of fusion of 2.06 kj/mol calculate the number of moles in a liquid sample of Na if sample releases 41.4 kj when it freezes?
Explain people working on pile influenced from debris : Why do you believe that there were so many first responders and subsequent people working on "pile" who were adversely influenced from debris on 9/11/01 at the World Trade Center site?
Compute how many titanium atoms : Compute how many titanium atoms are there in 24.1 grams of titanium and also determine what is the mass in grams of 3.23E+23 atoms of titanium.
Proportion of cases of recidivism : A prison official wants to estimate the proportion of cases of recidivism. In examining 250 convicts there are 65 cases. with 99% confidence interval what is the range? How do you figure this type of problem?
Hypothesize a molecular mechanism by nucleotide change : Smilin is a protein that causes people to be happy. It is inactive in many chronically unhappy people. The mRNA isolated from a number of different unhappy persons in the same family was found to lack an internal stretch.
Calculate how many gms of sodium iodide : determine How many formula units(formula un) of sodium iodide(NaI) are present in 9.54 grams of this compound and also calculate how many gms of sodium iodide are present in 6.07E+21 formula units of this compound.
Determine market structure of low-calorie food company : Determine the market structure in which the low-calorie food company operates and analyze short-run and long-run production and cost functions.
Determine what is the mass in gms : Phosphorus is combined with chlorine to give PClz a gaseous compound .calculate the value of z If you start with 2.097g of P and isolate 9.298g of PCLz .
Variation between levels : If 3 different factor levels show a lot of variation between levels this implies:

Reviews

Write a Review

Biology Questions & Answers

  Discuss the different orders of protein structure

Proteins discusses the different orders of protein structure. Explain why do you think it is that you can cook a pot roast where the meat proteins are altered by heating.

  Pcr to sequence a particular gene

Assume y ou wish to use PCR to sequence a particular gene that you have isolated. The sequencing protocol suggests that you use 3.2pmole (pico moles) of your primer in a 2 micro liter volume.

  Ligament and bones

The symptom of numbness of the palmar region often associated with carpal tunnel syndrome is caused by: Compression of the long extensor muscles of the hand. Compartmentalization of flexor and extensor muscles.

  Long term repopulating population

Discuss how do you know whether you have isolated a long term repopulating population or a short-term repopulating population?

  Calculate expected genotypic frequencies

In horses, the genes for white coat color and red coat color are codominant. Heterozygotes have a light red coloration, called roan.

  How stroke volume changed due to septic shock

T.J. and Tyler were building a tree-house. While searching for a board in a pile of used lumber, T.J. stepped on a rusty nail that penetrated deep into his foot, causing it to bleed.

  How could you test the hypothesis

Early in the morning, the black caterpillars rest in a tightly packed group on the east-facing surface of the tent. In mid afternoon, the group is found on the tent under surface, each caterpillar individually hanging from the tent by just a few of i..

  Species of organisms

Assume you wish to get a look at what species of organisms are in your mercury contaminated samples. How could you quickly identify the species present in this very large sample of unknown organisms?

  Find out one example of convergent evolution

Reverse transcriptase might be present in cells that have not been infected by a retrovirus since of the presence of what.

  Distinguish between the terms configuration and margin

Distinguish between the terms configuration, margin, and elevation. Describe the best way to view each of these characterisitcs?

  Percentage of the variation in growth

A analyzer discoveres that the correlation coefficient  between the exposure to a dangerous chemical and the growth of a certain species of butterfly is -.40.

  Procedure of protein synthesis

Describe the procedure of the protein synthesis.Describing the proposals for the future research within epidemiology.

Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd