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Researchers working on HIV (human immunodeficiency virus) and SIV (simian immunodeficiency virus) vaccines found that an antibody to a particular epitope of SIV (that was identical with the corresponding HIV-2 epitope) had a potent virus-neutralizing activity against numerous SIV and HIV-2 (but not HIV-1) isolates. This epitope was determined to be an octapeptide (= consisting of 8 amino acids linked in a polypeptide chain). This octapeptide was synthesized and used to immunize 20 individual rhesus macaques (Macaca mullata), but no protection against SIV in vivo was observed in the immunized animals. What could be the best explanation(s) for this peptide vaccine failure? Assess the following hypothetical explanations (1- 10) as either factually correct (= "true") or incorrect (= "false"):1. The peptide could not be processed by dendritic cells.2. The peptide could not be processed by B cells.3. The peptide could not be processed by activated macrophages.4. The vaccinations did not work, because the peptide was too long.5. The vaccinations did not work, because the peptide was too short.6. The vaccinations did not work, because the peptide was insufficiently complex.7. The vaccinations did not work, because the induced cytokine response was too weak.8. The vaccinations did not work, because T-cell epitopes were absent.9. The vaccinations did not work, because the octapeptide failed to activate NK cells.10. The vaccinations did not induce adequate amounts of interferon-? to activate professional antigen-presenting cells.
The nutritional data on a cereal box shows that one serving of a dry cereal has 200 kilocalories. If one were to burn one serving of the cereal,
Yellow tomatoes with a pear shape bring high price per basket to growers. Pear shape, yellow color, and terminal flower position are recessive traits produced through alleles, f, r, and t, respectively.
You want 1 L of 100 mu M NaCl, and you have 1 M stock solution. How much of the stock solution and determine how much dH2O will you measure out for this dilution?
Hereditary fructose interolance is a rare recessive disorder that is caused through a mutation in the aldolase B gene. As a result of this disorder individuals may have all of the following symptoms except:
The cuckolded only benefits at the expense of cuckolded perhaps benefits are washed away by loss of paternity in his own nest.
Hydrolases are one important class of enzyme that function to catalyze.
After one minute, ask your subjects to close their eyes. Once their eyes are closed, ask them to recite everything in the room that is different colour than the one they were looking for, for in case, anything and everything that is green.
Determine which variable is the independent variable--the variable that was controlled by the researchers? Is the independent variable on the x -axis or the y -axis?
During replication of viral DNA of members of the Polyomaviridae, a pair of T antigen hexamers forms a preinitiation complex at the origin for viral DNA replication.
A patient has been brought to you who is thought to have a mutation of the DVL1 gene, a human homologue of the Drosophila Disheveled gene.
At what stage of the cell cycle are the chromosomes satisfactorily condensed that they FIRST become visible under the light microscope.
A series of enzymes catalyze the reaction X Y Z A. Product A binds to the enzyme that converts X to Y at the position remote from its active site. This binding decreases the activity of the enzyme.
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