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You have been asked to investigate a specific human disorder, Crystal disease. The disorder is caused by a recessive mutation in the human gene A1. The disorder results in impaired vision, cognitive defects and early death. A short lived mutation has been isolated in butterflies which also causes neural degeneration and has been shows to affect the butterfly homologue of A1. A mouse homologue gene has been identified but is not cloned ( no one has isolated the gene sequence) and no mutations in the gene are known to exist. You are not a MD therefore cannot conduct human research. Two proposals has been submitted to you for evaluation. A. The first recommends using butterlies to conduct a suppressor screen for the phenotype associated with the mutation of A1. B. The second recommends generating a mouse model for Crystal disease. Explain how both would be conducted and provide a rationale for choosing one or the other approach. For A describe how you would perform the mutangenesis, what criteria you would use to identify suppressors, how would you clone and sequence the suppressor gene. For B explain how you would obtain the mouse sequence, how you would generate the knockout construct, how you would make the knock out mouse and how you would evaluate the reliability of the mouse model.
what is meant by increasing levels of organization in anatomy & physiology? What are the different levels & how do they relate to each other? What are examples for each level?
What is the origin of the inner mitochondrial membrane?
A guinea pig farmer, who is also a geneticist, wishes to produce a suitable breeding population. He crossed strain of true breeding small guinea pigs and true breeding large ones.
A sample of a gas occupies 1.40 x 103 mL at 25oC and 760 mmHg. What volume will it occupy at the same temperature and 380 mmHg?
The external environment is open directly to the peritoneal cavity of the abdomen and pelvis. This is one source of pelvic inflammatory disease.
Using one single color of bead, build a homologous pair of duplicated chromosomes. Each chromosome will have 10 beads with a di%uFB00erent colored centromere in it.
Several black guinea pigs of the same genotype were mated and they produced 29 black and 9 white offspring. What would you predict the genotypes of the parents to be?
Would a plant performing CAM idling be more likely to be using cyclic electron flow or noncyclic electron flow in the light reactions? Explain
how to keeping the shape of the cell. But I have found that there is a primary and secondary cell wall - each has their own function - so I am somewhat confused and looking for guidance.
How does the homeostatic mechanism regulate osmolarity or solute concentration of the blood in response to a meal high in salt?
What experiment would you design to determine the concentration of detergent that you could safely spread on the radish field that would reduce the germination rate of the seeds by only 10% compared with non-contaminated water?
A bowl of potato salad was left on picnic table for three hours on hot summer day. The microbial load was 300 CFU/g when the salad was put on table.
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