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How mistake in dna replication resulted in change amino acid

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How would a mistake in DNA replication resulted in a change in a amino acid (His 208 Tyr) of the Mc1r protein from a hisidine to a tyrosine in Sceloporus undulates, resulting in lighter skin?

I think perhaps a mistake could be during DNA replication, or perhaps a change in the mRNA sequence, but Im not sure about the in's and outs of it!

Reference no: EM13936741

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