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1. In the human genome, how many different MHC class I genes and MHC class II genes are there?
2. What are they called?
3. How many different HLA molecules would each individual roughly express?II
4. How would you describe the physical requirements of a relationship/association between a T cell TCR and MHC/peptide?
5. d o all TCRs that T cells start to assemble during their development in the thymus lead to a successful TCR?
6. Where do the peptides that are recognized by the TCR of T cells come from?
7. What specific parts or regions of a TCR generates the MHC/peptide binding component of the TCR?
8. Does the TCR bind to MHC and peptide or only MHC or only peptide?
9. When a T cell with its surface TCR is starting its journey through the thymus, what co-receptors does it express?
10. Will it always express these co-receptors? Explain your reasoning?
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