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Hardy-weinberg equilibrium

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Reference no: EM131538453

Consider a single locus with three alleles: A1, A2, and A3.

1) Write down all of the diploid genotypes possible at this locus. 

2) Derive the equation for the frequency of allele A1 as a function of the genotype frequencies.

Consider the following two datasets:

At the M locus: 

In a study of 1000 adults, the following genotype numbers were found: 

 M1M1 - 213 individuals 

 M1M2 - 489 individuals 

 M2M2 - 298 individuals

At the S locus: 

In a study of 4555 adults, the following genotype numbers were found: 

 S1S1 - 3564 individuals 

 S1S2 - 979 individuals 

 S2S2 - 12 individuals

Assignment: For both loci

  • Calculate the frequency of the alleles.
  • Calculate expected number of each genotype if the population were in Hardy-Weinberg equilibrium.
  • Identify which locus most clearly violates at least one of the H-W assumptions.

Reference no: EM131538453

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