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Several cell types have been proposed to create niches for Haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have not been systematically studied and no such factor has been conditionally deleted from any candidate niche cell. Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF; also known as KITL) is a key niche component that maintains HSCs. Here, using Scfgfp knock-in mice, we found that Scf was primarily expressed by perivascular cells throughout the bone marrow. HSC frequency and function were not affected when Scf was conditionally deleted from haematopoietic cells, osteoblasts, nestin-cre- or nestin-creER-expressing cells. However, HSCs were depleted from bone marrow when Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing perivascular stromal cells. Most HSCs were lost when Scf was deleted from both endothelial and Lepr-expressing perivascular cells. Thus, HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance.
Identify all the terms needed to bridge the gap between myofilaments and gross muscle, including connective tissue sheaths, using a diagram.
Explain all the anatomical features of the neuron. What are the structures and functions of each one?
Would you please concisely discuss what ideas from the Declaration of Independence you see as the most meaningful basis of our law today.
You are a training manager for the organization and should consider whether to make training in house or buy training from a vendor.
Write down three to five (3-5) page paper analyzing aptitude for charismatic leadership which includes the following: Introduction.
What were the major "breakthroughs" that contributed to a more scientific understanding of disease causation? Reference your response.
types/manner in which these assessments may be used. Identify three strategies or best practices that can address these ethical issues.
After the jury verdict is announced, Prosecutor Forbes is questioned by the local media concerning his exercise of the peremptory challenges.
I need some help on how to explain what is meant by the term plea bargain, and discuss its use in the criminal justice system today.
Develop a dialogue between three philopshers in which they discuss the following question: The epistemology of relativism is assumed to be true by many people.
These're the five different types of behavioral traps: The time delay trap the investment trap deterioration trap the ignorance trap collective trap.
Explain main ways that Franklin offers his story as illustration of self-improvement. Is he successful in attempt? What encourages him toward this attempt?
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