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Question
Hyperthyroidism
An 11-year-old female with no significant past medical history presented with unexplained weight loss (typically despite an increase in appetite), heat sensitivity, faster heart rate, more frequent bowel movements. She has also experienced a decline in grades at school. Family history is significant for thyroid disease in both grandmothers (both on thyroid replacement therapies). The clinician ordered thyroid function tests including Free T4, T3, TSH, anti-TSH receptor antibodies, antithyroglobulin and antithyroid peroxidase antibodies. The results for the tests follow:
The laboratory findings confirmed the clinical impression and a diagnosis of Graves's disease hyperthyroidism with thyrotoxicosis was made.
1. Which of the following confirms Graves disease
2. Why is she loosing weight despite increase in appetite?
3. After a year her T4 concentration was found out to be is 2.9 ug/dl (N=4.5-12.50 ug/dl). What would be her TSH levels? (N=0.2-3.5 mIU/L),
4. What symptom/s you will find if her T4 concentration was found out to be is 2.9 ug/dl?
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