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A microsatellite marker has been found to be linked to a rare autosomal dominant disease in humans and can therefore be used to follow inheritance of the disease allele. The reliability of this microsatellite marker as a predictor of the disease is related to the map distance between the marker and the gene causing the disease. Your patient is a man affected with the disease (genotype Dd) who is heterozygous for the V1 and V2 alleles of the microsatellite marker, with his V1 allele on the same chromosome as his D allele and his V2 allele on the same chromosome as his d allele. His wife is V3V3 dd (V3 is another allele of the microsatellite marker). She is pregnant and is undergoing genetic testing by amniocentesis to predict whether the fetus will have the disease. The results demonstrate that the fetus has the V1 and V3 alleles of the microsatellite marker. What is the probability that the fetus has inherited the disease allele D if the distance between the D locus and the microsatellite marker locus is: (A) 0 map units? (B) 2 map units? (C) 50 map units? Please explain how to do it. I already have the answers for it.
Draw the synaptic configuration of homologous pairs of chromosomes when one member is normal and the other member has sustained a duplication within the chromosome
Huntington's disease is expressed in individuals with at least 1-dominant allele, while albinism is expressed in individuals with homozygous recessive genotype
Fatty acid beta oxidation generates both NADH and FAD2. These are oxidized in the electron transport chain through
Suppose that a population of 1500 Tasmanian Devils is in H/W equilibrium for a gene that determines fang length. The allele for long fangs is dominant to the allele for short ones.
A microscope that gives the total magnification of 1500X, however image is too blurry to be useful. What might be the problem with this microscope.
How organismal respiration and cellular respiration are interconnected. While you visit him, his teeth are chattering, his skin is cool and clammy to touch, and he complains of feeling cold even though his room is quite warm. Elucidate his symptoms.
A and B are linked. Analysis of a linked RFLP in two purebreeding lines, AABB and aabb, demonstrate that the first was also homozygous for a long RFLP allele.
Which declaration is NOT true about DNA replication. Replication can only begin at distinct regions known as origins of replication.
Which food item would cook the fastest and why with reason. What are the similarities between G-protein receptor systems and Tyrosine-kinase receptor systems.
Mr Henry Wilson is a 54 year old bank manager who presents to the Emergency Department with a sudden onset of shortness of breath and left sided chest pain whilst watching the evening news.
Electrocardiogram results demonstrate a shortened QT interval and an rise in the P-R interval. Laboratory results indicate that his serum potassium level has increased to a value of 6.5 mEq/L.
Draw the tripeptide His Glu Ala, with charges, at pH 5. Recognize the C-terminus, the N-terminus, a peptide bond.
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