Explain why there has been evolution of testing platforms

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Problem

Almost all of the FDA-approved companion diagnostic (CDx) tests as of early 2021 have targeted various types of cancers. This discussion forum will focus on certain aspects of CDx tests, especially with respect towards cancer disease management. There are two areas of focus.

Topic I: Provide a rationalization for why CDx tests have at least for the first 20 years of their existence been primarily focused on cancers. This should address the evolving understanding of cancer biology and the efficacy of treatments before and after CDx tests existed and using at least one real world example. Get the instant assignment help.

Topic II: PCR and NGS tests have been by far the most prevalent for CDx tests but early on most of the CDx tests were using in situ hybridization (ISH) and immunohistochemistry (IHC). Explain why there has been this evolution of testing platforms for CDx testing. This should include include the disadvantages of ISH and IHC, as well as the advantages of PCR and NGS.

Reference no: EM133838574

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