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A brilliant scientist has discovered a new anti-inflammatory agent, Xious, that is capable of preventing the onset of, and therapeutically down-regulating the inflammatory response in several animal models of inflammatory autoimmunity. Prior to human trials it is critical to determine if Xious compromises treated individuals in their ability to respond to microbial infections. To test this, the murine model of cutaneous infection with Staphylococcus aureus was utilized.
In this model, mice are inoculated subcutaneously with synthetic beads coated with S. aureus. The development, and then healing, of skin abscesses is the mechanism utilized to test the immunological response. Mice received either therapeutic doses of Xious or a placebo prior to infection. Mice treated with Xious developed significantly smaller abscesses compared to placebo treated mice. Explain the two conclusions that may be drawn from this outcome. Identify what information you would need to know to distinguish between these two conclusions.
Use the cleland representation create the reaction progress of thrombin, a serene protease using a ping pong mechanism on the hydrolysis of the substrate Ala-Arg-Gly-Ala
The OD of an E.coli culture is 0.23. You transfer 300 µl of this culture into 29.7ml of medium. You continue this same dilution one more time. You transfer 50 µl of your last dilution onto an LA plate. After 24 hours of incubation, you observe 11 ..
Scientists can use mutants to study metabolic pathways. These organisms have mutation in gene encoding a metabolic pathway enzyme that results in inactivation of that enzyme.
q1what do you think about cooperative breeding? when is it advantageous to be a helper to your kin versus going off to
Suppose you have a population of 150 butterflies, but a wild fire devastates the population and only 24 butterflies survive. What percent does the colony decrease by?
Part A) In what interval range does the P value fall, if a chi-square test of experimantal data produces a chi-square value of 14.45 with 6 degrees of freedom?
Describe specific extrachromosomal inheritance mechanisms associated with mitochondria, chloroplasts, and infectious particles. What type of experiments would you design to determine whether or not a particular phenotype is nuclear or extrachromos..
How do restriction enzymes and ligase allow us to clone fragments of DNA? How are cloning vectors then put into bacteria cells? How do we know if the bacteria cell has the vector? How do we know if the vector contains the insert? How is a cloning vec..
q1. a technician in your lab has fractionated the parts of a cell and done chemical analyses of each fraction other
During the nineteenth century, the new theory of evolution was criticized on grounds that if an advantageous variant trait happened to appear in a population,
Discuss research of the parasitic relationship between the Nosema whitei and the hosts the red flour bettle.
Why is depth of field important in studying biological structures? How can it affect your ability to find and examine a specimen?
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