Reference no: EM132695182

-For patients with BLS 1, their cells may express up to 10% of the MHC class I relative to healthy controls. Although BLS 1 patients may have a homologous non-sense mutation for a TAP-1 or TAP-2 gene, how would you account for the observation that their cells may express up to 10% of the MHC class I proteins relative to healthy controls?

-In patients with suspected BLS II is made, a bone marrow transplant is often considered before a definite diagnosis has been confirmed. Why do you think this is?

-For BLS II patients that undergo successful hematopoietic stem cell transplant no longer have the severe combined immunodeficiency phenotype, and have the antibody responses by B cells improves considerably. However, their total T cell counts are only about 20% of normal. These patients do not have a thymus transplant when they receive the hematopoietic stem cell transplant. How would you explain the partial restoration of their T cells? Why don't they have 100% of the normal T cell count?