Reference no: EM132657995

Question 1:
Read the article, 'Cranberry Juice Fads to Prevent Recurrent Urinary Tract Infection: Results from a Randomized PIaceboi Controlled roar by Barbosa.Cesnik et al.

It is ok if you don't understand every word of the statistical analysis and results. Focus on the Methods section and the Discussion

Answer the following questions based on the article. In general, 24 sentences should be sufficient for each response but feel free to write more if you wish.

a) In your own words, describe the exposure that was assigned to each group in this randomized trial.

b) In the Discussion, the authors state: 'Although previous studies in similar study populations...have shown a significant reduction in UTI recurrences. these studies were not blinded...". 1 What methods were used for blinding the participants and investigators in this study, ii. How could the lack of blinding in previous studies have contributed to contrary results?

c) Explain how the authors dealt with noncompliance in this study. i. How was noncompliance defined in this study?  How were the results from the non-compliant subjects analyzed? Were there differences in noncompliance between the exposed and unexposed groups?

d) Based on the methods described in this randomized controlled trial, assess the internal validity of the study. In other words, do you believe the study to be internally valid? Explain.

Question 2:
In your own words, explain the difference between Internal Validity and External Validity in Randomized Trials. Why is each important? What is the relationship between them?

4-6 sentences should be sufficient to answer this question, but feel free to write more if you wish.

Article - Cranberry Juice Fails to Prevent Recurrent Urinary Tract Infection: Results From a Randomized Placebo-Controlled Trial