Differentiation sequence of human b cells in the bone marrow

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Which of the following events occurs first in the differentiation sequence of human B cells in the bone marrow?

Cytoplasmic mu chains present in the B cell

Immunoglobulin heavy chain rearrangement

Immunoglobulin light chain rearrangement

Surface IgD and IgM present on the B cell

Surface IgM present on the B cell

Reference no: EM13269458

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