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Yeast alcohol dehydrogenase catalyzes the conversion of acetaldehyde to ethanol, and important enzyme for all brewers of beer and bakers of bread. Load the structure of this enzyme (pdb =1AXG).
a. Draw a "roadkill" diagram showing all importantinteractions between the bound NAD and the enzyme (use chain A).Hint: start by drawing the structure of NAD (see page 327) and then"build" all the interactions onto that structure.
b. The "business" end of NAD is the nicotinamide ring,which does hydride transfer to the acetaldehyde substrate. How welldo you think the enzyme will work with an NAD analog that containsonly the nicotinamide ring? Why or why not?
Hair splits most easily along its fiber axis, whereas fingernails tend to split across the finger (sideways) rather than along it. What are the directions of the keratin fibrils in hair and in fingernails? Explain your answer in molecular terms.
A person has a tidal volume (TV) of 450 mL and his anatomical dead space (ADS) is 150 mL. His respiratory rate is 10 breaths per minute. What is his alveolar ventilation rate? please show calculation and correct units.
Scientists surmise that an early charophyte-like alga is theancestor of land plants. Starting with bryophytes, describespecific features that evolved in this group of plants that allowedfor a move to land.
Explain why a deficiency either of vitamin B12 or of folate causes red blood cells to be larger than normal.
Briefly explain why hydrogen bonds and salt bridges do not contribute much to protein stability at room temperature.
For a specific type of cells after 3 hours, the concentration of cells per milliliter of solution is about 400/mL. After 10 hours, the concentration has gone up to 2000/mL. Determine the initial concentration of cells.
The DNA molecule is permitted to replicate in a solution containing all four unlabeled deoxyribonucleoside tripohosphates and deoxyadenosine triphospage that is labeled with 32P.
The use of PCR and genetic approaches in biotechnology
What is the most possible explanation. Cultures from dialysate concentrate and the internal areas of the dialysis machines were negative; iodophor from a small in- use plastic container yielded a pure culture of P. aeruginosa. What improper method le..
People with a deficiency in the AIRE protein suffer from a broad spectrum autoimmune disease that involves immune attack against a diverse set of body tissues and organs.
Her breath smells like acetone and her blood glucose test out at 650mg/100ml of blood. She is in acidosis. What hormone must be administered to her and why. Where may she find such DNA.
Consider the HIV enzyme called protease. The amino acid residues at the active site are highly hydrophobic. In designing a drug that would bind to the active site and jam it, researchers should use which sort of molecule.
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