Describe the pathophysiology of pernicious anemia

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Reference no: EM133917823

Case Study:

At the age of 70, Mrs. Anderson started noticing generalized weakness, fatigue, and an unexplained weight loss of 10 pounds over three months. A complete blood count (CBC) was done as part of her diagnostic workup. Portions of the CBC that were abnormal were reviewed. Abnormal findings in the CBC were:

Red blood cell count (RBC) of 3.20 million/mm3
mean corpuscular volume (MCV) of 130 μL
reticulocytes 0.4%,
hematocrit (HCT) 25%,
hemoglobin (Hgb) 7.9 g/dL.

Suspecting pernicious anemia, her Primary Care Physician ordered a Shilling test. After reviewing the results of the schilling test, Mrs. Anderson was diagnosed with pernicious anemia and started on vitamin B12 injections. She currently returns to her Primary Care Physician every month for her vitamin B12 injections.

Questions:

1. Briefly describe the pathophysiology of pernicious anemia.

2. Identify possible causes of vitamin B12 deficiency.

3. Identify the physical assessment findings that are characteristic of pernicious anemia.

4. To help make a definitive diagnosis of pernicious anemia, a Schilling test may be performed. Describe the Schilling test.

5. Patient teaching: Identify five foods rich in vitamin B12 that Mrs. Anderson should consider.

6. Discuss the standard dosing and desired effects of the vitamin B12 injections for the client with vitamin B12 deficiency.

Reference no: EM133917823

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