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A genetic mutation occurs that alters the specificity of the Golgi enzyme that phosphorylates mannose residues in the oligosaccharides of glycoproteins. The effect of the mutation is such that the enzyme now indiscriminately and randomly phosphorylates mannose residues on all glycoproteins passing through the Golgi complex.
A. What is the normal role ofthis enzyme?
B. What is the normaldestination of Golgi contents that are phosphorylated on mannoseresidues and how do they get there?
C. What are the consequences ofthis mutation?
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In cattle, coat color may be white, black, or black and white spotted. When true breeding white cattle are crossed with true-breeding black stock, the F1 is all solid white.
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