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Several mutational changes to proteins involved in apoptosis are listed below.For each, indicate whether you expect it to have a dominant-negative phenotype. In other words, do you expect it to cause a defect in apoptosis even in cells that also contain the normal protein? Explain your answer.
A. Deletion of death domain of Fas death receptor.B. Mutational change to Fas ligand that prevents its oligomerization.C. Deletion of the death effector domain of FADD.D. Deletion of the death effector domain of procaspase-8.E. Deletion of the CARD domain of Apaf-1.F. Mutation of the catalytic cysteine of caspase-8 to serine.G. Mutational change to Bax that prevents its oligomerization with itself and with Bak.H. Mutational change to IAP that increases its affinity for caspases.
what fraction of the progeny will have Ab or aB phenotype?
What would be the limiting factor for ATP production by glycolysis in a strenuously-exercising muscle that lacks lactate dehydrogenase?
Compared to impact craters on other moons, young impact craters on Europa (including the Pwyll impact crater) show a distinct absence of high crater walls, or any significant depression towards the center. What does this suggest about Europa's icy..
Would you expect cancer to arise more often in types of cells that divide frequently (i.e. skin cells) or in types of cells that divide rarely or not at all
What is your understanding of Metabolism, Catabolism & Anabolism Relate to the interest of environmenmtal scientist in plastic waste(think about recycling in particular)
q1. what amount of the molecules produced in the experiment are directly of use for the cellular metabolism and cell
Determine which of the following observations are testable. For those that are testable.
Draw a negative feedback loop showing how sympathetic and parasympathetic nerves are affected in someone experiencing a fall in blood pressure (the initial stimulus). Keep in mind that the sensor detects the fall in blood pressure.
Explain the directed mutation hypothesis (1). Describe an experiment that has tested this hypothesis (2). What was the outcome of this experiment (1)? What did this experiment teach us about how mutation and natural selection interact during evolu..
Why do you suppose E. coli has three different DNA polymerases? Why do eukaryotes have more DNA polymerases?
The rough ER is the site of synthesis of many different classes of membrane protein. Some of these proteins remain in the ER, whereas others are sorted to compartments such as the Golgi apparatus, lysosomes, and the plasma membrane (PM).
mr. smith was admitted to the hospital for surgery on his left knee. when mr. smith woke up from the anesthesia he
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