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Biostatistics and Epidemiology-1. Define sensitivity and specificity
2. A cancer screening test is being applied in a population of 200 men who were also evaluated through the biopsy of tumor. 30 of the men were confirmed having cancer through biopsy. Out of these 30, 25 were also found to have cancer through the screening test. Screening test also found 15 cases to be having cancer but this was not confirmed by biopsy. Based on this information draw 2 x 2 table showing numbers in each of the 4 cells and compute sensitivity, specificity, Positive predictive value and Negative predictive values of the test for presence and absence of the disease.
3. Define positive predictive value (PPV) and negative predictive value (NPV).
4. An epidemiologist in Saudi Arabia wants to study the efficacy of iron supplementation for the prevention of HIV infection. He wants to make sure that only subjects who are free of HIV infection are enrolled in his trial. Based on the outcome of the test, he decides who could participate in his iron supplementation trail.
What are the four most important elements necessary for life on this planet? Name the four most important groups of organic molecules for life? Give an example of each.
In a series of experiments, genes that code for mutant forms of a receptor tyrosine kinase are introduced into cells. The cells also express their own normal form of the receptor from their normal gene.
Discuss similarities and differences Rickettsia rickettsii and Chlamydia trachomatis with respect to structure, disease transmission, and pathogenesis.
Through writing Henderson hasselback equation describe how pH is equal to pkA when exactly one half of lactic acid is dissociated into H+ and A- ions through titrating with 0.5M equivalents of NAOH.
Eighteen museum specimens of the extinct great Auk were used to amplify coxI, a mitochondrial gene for cytochrome oxidase. DNA sequence analysis of 600 nucleotides of coxI revealed 5 alleles and the number of nucleotide differences between them are s..
in rabbits black fur is dominant to brown and long hair is dominant to short hair. a male is mated to several brown
A protein has a molecular mass of 200 kDa as determined by gel filtration (=native molecular weight). When separated by SDS-PAGE (without a reducing agent present) only one polypeptide appeared with a mass corresponding to 100 kDa.
1 what are the three major species of staphylococcus? why one of them is more pathogenic compared to the other two
why can an injection of potassium chloride be fatal? (it something to do with action potentials)
If an enzyme with no inhibitor has a Vmax of .091 abs/min and a Km of .31 mM. An inhibitor is added (1 uM) which changes the Vmax to .036 abs/min and a Km of .13 mM, so it has a Ki of -1.72 and a Ki' of .65 uM.
q1. thirteen-year-old ryan has begun to challenge numerous of his parents values and to express his own set of highly
How does your individual TRC and those of the average of class compare with the average TRC of the general population as reported by Holt (1968) as 145 for male and 126 for female.
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