Calculate the renal clearance for the patient

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Reference no: EM133836360

Problem

A drug is given as a single 200 mg dose orally. The oral bioavailability is 95 %. The total amount of drug recovered unchanged in the urine is 125 mg. If the elimination half-life of the drug is 3.3 h and its volume of distribution (Vd) is 58 liters, calculate (a) total body clearance (Clt) and (b) renal clearance (CIR). Get the instant assignment help. Calculate the Renal Clearance for this patient if he develops 60% renal impairment.

Reference no: EM133836360

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