Reference no: EM133445111
1. The following table lists typical pharmacokinetic parameters and dosing regimens for acetaminophen, ibuprofen and naproxen, three non-prescription analgesic/antipyretic agents.
DRUG F Vd (L) CL (L/h) Dosage regimen
Acetaminophen 0.9 67 21 1000 mg/6 h
Ibuprofen 0.7 10 3.5 400 mg/6 h
Naproxen 0.95 11 0.55 500 mg/12 h
- Calculate the average plasmatic concentration at steady-state for these three drugs when patients are on the regimens given in the table.
- For which of the three drugs is the steady-state reached the fastest?
- For which of the three drugs is the degree of accumulation the greatest on the regimens given in the table.
- Assuming very rapid absorption and distribution (Ka>>>K), calculate the maximum and minimum steady-state plasmatic concentrations of ibuprofen and naproxen on the regimens given in the table.
2. Ampicillin has the following average pharmacokinetic parameters in a 70 Kg patient:
F(oral)= 0.6; Vd=20L; CL=160 mL/min; Ka=1.5/h
Determine if 500 mg/6 h is the correct dosage regimen in order to keep the plasmatic concentration above the minimum effective concentration of 0.39 mg/L (MEC against a microorganism producing the patient's infection).
3. The antibiotic tetracycline shows the following PK parameters: Vd=1.5 L/Kg, Oral Bioavailability=75%, half-life=10 h, constant rate of oral absorption (Ka)=0.9/h, and MEC= 2 mg/L. Validate the dosing regimen of 500 mg every 8 hours in a 81 Kg patient
4. A 70 Kg-patient is being administered for several months with a daily oral dose of 0.25 mg of a drug showing a half-life of 18 hours. The patient is exhibiting toxicity to the drug and a blood sample showed a plasmatic concentration of 2.8 ng/mL. The therapeutic range of this drug is from 0.7 to 2 ng/mL. For how long should the patient wait until the new dosing regimen is started?
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