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Assume you have been examining a new drug that binds to PPAR? and produces its beneficial effect (increased insulin sensitivity). When you give this chemical to mice, you see kidney damage. Other PPAR? drugs did not lead to the same toxic effect and in a PPAR? knockout mouse you still see kidney damage. However, the type of damage that you see resembles drugs that affect another receptor called ROR. When ROR is knocked out in mice, you no longer see kidney damage, but you still see the beneficial effects. Which of the following is correct?
A) ROR is the ontarget receptor and PPAR? is the offtarget receptor
B) ROR is the offtarget receptor and PPAR? is the ontarget receptor
C) ROR activation is the doselimiting effect and PPAR? activation results in the chemicalmediated toxicity
D) ROR activation results in chemicalmediated toxicity and PPAR? activation results in the doselimiting effect
E) Other ROR drugs will result in increased insulin sensitivity
In order to separate the RNA you majorly utilize a protein denaturant solution of the guanidinum salts. These chaotropic solutions denature by disrupting the H- bonding.
Determine when glucose is metabolized in the respirating celll to H2O and CO2, free energy change of the reaction is equal to that obtained when glucose is combusted with oxygen in a calorimeter chamber.
What kind of measure is useful in investigating the epidemics? Enlist the steps you would carry out for detecting or investigating an outbreak.
create a specific experiment to measure the rate of cellular respiration in an organism of your choice
What is the gene order? What are map distances in recombination units?
A patient lost a lot of blood during surgery and his blood pressure dropped from 120/80 to 90/50. Describe how the kidneys respond to this change in blood pressure.
Acetylcholine binds this membrane protein, which subsequently opens to allow sodium to enter the cell. Acetylcholine exerts its effect on what kind of transport protein.
Albinism is a condition that results from the lack of normal pigmentation. In humans, individuals with two recessive alleles at ALBINO (aa) locus are albino.
Yeast grows as a haploid cell. In the wild type cells in presence of O2, the pH of mitochondrial matrix is 8, however in cells along with this mutant S gene, the pH is 7. Explain all these results.
Describe the most suitable measure of incidence of diabetes in this scenario? Find the risk (ie measure of Incidence identified in part c) of developing type 2 diabetes among females in this community.
After leaving the end of a ski ramp, a ski jumper lands downhill at a point that is displaced 66.2 m horizontally from the end of the ramp.
Name the bones of pectoral girdle and the bones of the pelvic girdle. Evaluate the pectoral and pelvic girdles with regard to strength, versatility, and function.
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