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Question: Ethanol (Mr 46) in the body is oxidized to acetaldehyde by liver alcohol dehydrogenase (LADH). Other alcohols are also oxidized by LADH. For example, methanol (Mr 32), which is mildly intoxicating, is oxidized by LADH to the quite toxic product of formaldehyde. The toxic effects of ingesting methanol (a component of many commercial solvents) can be reduced by administering ethanol. The ethanol acts as a competitive inhibitor of methanol by displacing it from LADH. This provides sufficient time for the methanol to be harmlessly excreted by the kidneys. If an individual has ingested 100 mL of methanol (a lethal dose), how much 100 proof whiskey (50% ethanol by volume) must be imbibed to reduce the activity of the LADH towards methanol to 5% of its original value? The adult human body contains ~40L of aqueous fluids throughout which ingested alcohols are rapidly and uniformly mixed. The densities of ethanol and methanol are both 0.79 g/cm3. Assume the Km values of LADH for ethanol and methanol to be 10-3 M and 10-2 M, respectively, and that Ki = KM for ethanol
Recalling a significantly emotional past event or feeling can elicit the same physiological response as the original event.
The most significant probable cause of this temporary apnea is decreased activity of the what. what is the probability that the next child would be a girl.
Describe b riefly the role of HOX genes in brain development. If a twenty-five year old woman using Accutane to treat acne discovers that she is pregnant, what concerns do you have for the embryo/fetus?
Describe why it may matter if the county had dry areas, swampy areas, forests, and meadows all within its boundaries. As a doctor, which of the statements are important factors for you to consider as you decide whether or not to remove the patient's ..
Why is it significant for clinical laboratory personnel to follow proper methods of sterilization and specimen control.
explain Why is it advantageous for citrate the product of reaction 1 of the TCA, to inhibit phosphofructokinase, which catalyses the third reaction in glycolysis.
A is recessive and confers a black coat, A is dominant to a and confers an agouti coat, and A Y is dominant to both and confers a yellow coat.
Some times in the movie, politics of science were discussed. Explain how politics played a role in the discovery of DNA structure. Do you think the science of today is more or less political than it was during the 1950s? Examine one instance of moder..
Discuss embryonic stem cell invitro methord in which transgenic animal were generated and efficient show how homologous recombination happening?
Actions of the biceps brachii muscle include: supination of the forearm, Flexion of the shoulder, Flexion of the elbow.
A patient lost a lot of blood during surgery and his blood pressure dropped from 120/80 to 90/50. Describe how the kidneys respond to this change in blood pressure.
Data from enzyme kinetic studies of an enzyme at specific substrate concentration. Data below also include from studies with town different inhibitors.
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