Kiss-and-run cycle

Also a much faster kiss-and-run cycle operates at the central synapses. In this the vesicle membrane fuses with the presynaptic membrane to open a pore throughout those transmitter discharges, afterward which the pore closes and the vesicle disengages. There is no complicated endocytosis. As this mechanism has a cycle time of only 1 s it is capable to support extended periods of high release with only 35–40 vesicles in the recycling pool.