Standard error of the differnce between means., Basic Statistics

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IN two separate studies, the actual difference between the means of a treated group and untreated group is 3 points. However, in one study sm1-m2 is very large and so the 3 points is not fund to be significant. In the other study sm1-m2 is very small and so the 3 points is found to be significant. What might have caused this big difference in the sm1-m2 for the two studies?

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