## Define informed consent, Advanced Statistics

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Informed consent: The consent needed from each potential participant former to random assignment in the clinical trial as speci?ed in the year 1996 version of Helsinki declaration intended to guide the physicians conducting therapeutic trials, namely: in any kind of research on human beings, each potential subject should be adequately informed of the targets, methods, anticipated advantages and potential hazards of the study and the discomfort it might entail. He or she should be informed that he or she is at liberty to abstain from the participation in the study and he or she is free to extract his or her consent to participation at any time. The physician must then obtain the subject’s freely-given informed consent, preferably in the writing.

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