Clotting mechanism, Biology

Clotting Mechanism

Four substances are necessary for coagulation of blood; prothrombin, thromboplastin, calcium and fibrinogen. Prothrombin gives rise to thrombin, an enzyme. Fibrinogen, prothrombin, and calcium are present in circulating blood. Thromboplastin (a lipid or fat-like compound containing phosphorus) is widely distributed throughout the tissues, the lung and brain being especially rich in this factor. It is absent or present in only small quantities in blood plasma. When blood is shed, thromboplastin is liberated from injured tissue and probably also from the leucocytes of the blood itself. The thromboplastin, acting upon the prothrombin in the presence of calcium in an ionised form, converts, it to active thrombin. Thrombin acts in turn upon the inactive fibrinogen, converting it into insoluble fibrin which is deposited as fine threads to form the framework of the clot. In simplest possible terms the chief factors are summarised in the following scheme:


248_Clotting Mechanism.png

Blood does not normally clot in the blood vessels because there is not sufficient free thromboplastin to convert the inactive prothrombin into the active thrombin.

Posted Date: 1/16/2013 12:29:20 AM | Location : United States

Related Discussions:- Clotting mechanism, Assignment Help, Ask Question on Clotting mechanism, Get Answer, Expert's Help, Clotting mechanism Discussions

Write discussion on Clotting mechanism
Your posts are moderated
Related Questions
What are the main human degenerative diseases? The main human degenerative diseases are separated into three groups: cardiovascular diseases, neoplastic diseases and degenerat

Explain sol -gel transformation During sol -gel transformation, a three dimensional network is formed by the interlocking of dispersed particles. The liquid phase is entrapped

How to find the number of pair of alleles involved in polygenic inheritance using the number of phenotypical forms of the trait they condition? Considering the "p" number of th

Amiodarone, quinidine, propafenone, and verapamil may increase digoxin levels up to 100 per cent. It is prudent to measure a blood level after 7-14 days (and at least 6 hours after

a solution of 5mMol/L CaCl2 is separated from a solution of 1 micromole/L CaCl2 by a membrane that is selectively permeable to Ca+2 but is impermeable to Cl-1 what are the magnitu

Q. How Boiling used for sterilization? Though highly unreliable as a sterilization technique and more effective for disinfection, it is used very often. Boiling water in hot wa

REASON S FOR GROWTH OF POPULATION - The human population explosion is mainly a result of reduced death rate. Main reasons for it are - 1 .       Protection from natura

Explain Clinical dietetics and Diet therapy Clinical dietetics  :  The application of  dietetics  in a hospital or health care institutional  setting. Diet therapy  :

What are zymogens? Zymogens, or proenzymes, are enzymes secreted in inactive form. Under some conditions a zymogen shifts to the active form of the enzyme. Zymogen secretions i

CYTOCHEMISTR Y OF PROTOPLASM - It is supper mixture or mixture of mixtures . 3 4 elements present in it. 1 3 elements are universal. e.g. C, H, O, N, P, K, S,