Which marker appears to be closest to the trait allele

Reference no: EM131255794

The table below gives the Z scores for four different marker loci (A, B, C and D) with respect to possible linkage to a monogenic, fully penetrant trait.

E	0	0.05	0.1	0.15	0.2
Z(A)	-3.0	-2.0	-1	0	0.3
Z(B)	0.1	0.2	1.0	0.6	0.3
Z(C)	4.0	3.0	2.0	0.8	0.2
Z(D)	∞	2.0	4.0	4.2	2.5

a. Which markers is/are significantly linked to the trait allele anywhere within 0≤È≤0.2?

b. Which marker appears to be closest (fewest cM away) to the trait allele?

c. Which markers, if any, definitely is/are NOT linked to the trait allele specifically at È=0?

(they may be linked at other values of È)

d. For which markers, if any, can we make no definite conclusion about linkage?

Reference no: EM131255794

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