What mutation could invert the topology totype III

Reference no: EM13531235

A protein is inserted in the ER membrane with type II topology (N -terminus in cytosol). What mutation could invert the topology totype III (C-terminus in cytosol)?

a) The positively charged residues N-terminal of the Signal Anchorsequence need to be mutated and positively charged residues C-terminal of the Signal Anchorsequence need to be added.
b) The positively charged residues N-terminal of the Signal Anchorsequence need to be mutated.
c) positively charged residues C-terminal of the Signal Anchorsequence need to be mutated.
d) None of the above.

Reference no: EM13531235

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