Develop a model for vancomycin hci

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Reference no: EM131340772

Develop a model for vancomycin HCI, which is a treatment for serious infections by susceptible strains of methicillin-resistant staphylococci in penicillin-allergic patients. The drug is administered by IV infusion. The intravenous dose is usually 2 g divided either as 500 mg every 6 h or 1 g every 12 h, and the rate is no more than 10 mg/min or over a period of at least 50 min, whichever is longer. When kidney function is normal, multiple intravenous dosing of 1 g results in mean plasma concentrations of about 63 µg/ mL immediately after infusion, 23 µg/mL in 2 h, and 8 µg/mL 11 h after infusion. In such patients, the mean elimination half-life from plasma is 4 to 6 h. The mean plasma clearance is approximately 0.058 L/kg/h (liter of drug per kilogram of patient mass each hour), while the mean renal clearance is about 0.048 L/kg/h (Hospira 2010). Thus, include the mass of the patient in the model.

Reference no: EM131340772

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