Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Because the genetic code is a universal code in biology, in general the nucleotide sequence of important genes is highly conserved across many different species of organisms. It is very common for 70% or more of the nucleotides in a gene to be conserved among very different organisms. Redundancy in the genetic code allows for small differences in the nucleotide sequence for a given gene without significant variations in the amino acid sequence of a protein. For example, the nucleotide sequence of the gene for insulin, the peptide hormone required for glucose uptake by many body cells, is well conserved (greater than 80% similarity) in many vertebrate species. As a result of this conservation of nucleotide sequence, comparing the peptide sequence for insulin from cows, humans, sheep, dogs, and rats often shows fewer than six or seven differences in amino acid sequence. However, point mutations in certain positions of a codon can create changes that dramatically alter the protein produced. Examples of mutations of this type include frameshift mutations. To help you understand why the nucleotide sequences for important genes are highly conserved, work together in a group of four or five students to complete the following assignment. Imagine that you have just purified a new protein from the brain of adolescent males that you believe may be responsible for excessive hair-combing behavior. From peptide-sequencing experiments, you have determined that this protein contains the following peptide sequence: Trp-Met-Asp-Gly-Trp-Met. Determining the nucleotide sequence of mRNA that was used to translate this part of the protein will enable you to identify the chromosomal location of this new gene and allow you to isolate and clone this gene. It is known that this peptide sequence is highly conserved among males that demonstrate excessive hair-combing behavior which suggests that this portion of the protein is important for its functions. In addition, a mutant form of this protein has also been discovered that appears to result in the loss of the excessive hair-combing behavior. This mutant sequence arises from a single point mutation in the nucleotide sequence of the normal (wild-type) gene for this protein that creates a frameshift mutation. The peptide sequence from this mutant protein is Met-Tyr-Val-Cys-Met- Tyr. Use TranslationLab to complete the following exercises. Determine the sequence of a mRNA that could be used to translate this peptide. Can you determine another sequence of mRNA that would also code for this peptide? Why or why not? Explain your results. Once you have deciphered the mRNA sequence for the normal protein, introduce changes in this sequence until you have determined the nucleotide sequence that specifies the mutated peptide sequence. Examine this mRNA sequence and identify the codon or codon(s) that were altered to create the mutant peptide.
You want to make one liter of a solution containing 10 mg/ml sodium phosphate, 10 mg/ml sodium chloride, and 10 mg/ml potassium nitrate. How much of each starting solution do you need to use, and how much water do you need to add
Dr. Paul is blood type O. His father was blood type A and his mother was blood type B. What were the genotypes of his parents and what are the possible blood types and ratios expected for crosses involving these parental genotypes?
If a lipid raft is typically 70 nm in diameter and each lipid molecule has a diameter of 0.5 nm, about how many lipid molecules would there be in a lipid raft composed entirely of lipid?
Person onlong term drug therapy shows high percentage of nonhemamtopoietic connective tissue. What does this mean? What short term and long term treatments zre indicated? WIll infusion of whole blood or packed red cells be more likely?
Assume you have identified a mutant E. coli strain that cannot synthesize histidine. To determine the location of the his- mutation on the E. coli chromosome.
effects on the human body of taking chemical substances to enhance performance improve health or address specific
Use the Goldman equation and the Goldman equation simulator to answer the following questions. When answering %u201CWhy%u201D questions, do so in one-two sentences.
Which is the most effective and why? Please explain by providing specific examples to support your choice.
what would you predict would be the mean ear length of their offspring and What is heritability of ear length in rabbits?
i. explain how the name of a muscle can distinguish its location action shape and function. select five different
A bag made from dialysis membrane contains an aqueous solution of 2mM protein and 0.25mM sodium Iodide (NaI). The bag is carefully weighed and placed into an aqueous solution of 1.0 mM starch and 0.5mM sodium chloride (NaCl).
Under physiological conditions, [glucose] = 5 mM, [g-6-P] = 80 μM, and Pi = 1 mM. Under these conditions, will the reaction go spontaneously from left to right? [Note: the concentration of water is always taken to be 1 M]
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +1-415-670-9521
Phone: +1-415-670-9521
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd