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As you continue on in your career, you become keenly interested in the mechanisms of immune cell recruitment during the innate immune response. After years of graduate work, you discovered a new cytokine (X), which chemoattracts neutrophils. In your excitement you begin devising experiments to characterize the function and relevance of cytokine X. From what you know of chemokines, predict the general structure of chemokine X and its cognate receptor.Where, by what cell types, and when would you expect it to be expressed? Explain, experimentally, how you would test your hypothesis.What is the effect of expression of chemokine X on the immune response. Explain, experimentally, how you would test your hypothesis.
As you are working in the lab, you obtain a major career-defining result. You have discovered a new TLR (TLR15), which recognizes either a bacterial or viral antigen. Your task to finish graduate school is to fully characterize the molecule.Design an experiment to determine if your new TLR15 recognizes a bacteria or a virus. What results do you anticipate and what experimental difficulties will you potentially encounter?Comment on the likely structure for the molecule and indicate a plausible signaling pathway for cellular activation.Where in the cell would you expect to find this new TLR? Why? Please design and fully explain two different experiments to test your hypothesis.What are the consequences of deficiency of TLR15? Please design and fully explain two different experiments to test your hypothesis.
Make a diagram of a cell (2n=10) at mitotic metaphase. Demonstrate the cell membrane, the spindle, and each of the Chromosomes as they are aligned on the metaphase plate
make a discussion on the feasibility of using methylation analysis
Purines and pyrimidines play crucial part in cellular energy systems signaling and in the production of DNA and RNA.
Life arose in water. Explain w hy do you think colonization of land represented a major evolutionary step in the history of life?
The Meselson-Stahl experiment was repeated for a unicellular eukaryote (2N=6) & we learned that DNA replication is semiconservative in eukaryotes.
A analyzer discoveres that the correlation coefficient between the exposure to a dangerous chemical and the growth of a certain species of butterfly is -.40.
T.J. and Tyler were building a tree-house. While searching for a board in a pile of used lumber, T.J. stepped on a rusty nail that penetrated deep into his foot, causing it to bleed.
Discuss how temperature affects the hemoglobin saturation curve and how does temperature affect the delivery of oxygen to the tissues?
Compute the number of ATPs generated from one saturated 12-carbon fatty acid. For this question, suppose that each NADH molecule generates 2.5 ATPs
Describe the event that are invovled in the release of neurotransmitter from nreve endings?
Discuss the five main types of histone proteins, and describe what role each of them plays in the nucleosome. Based on what you know about them,
Degrade a monoglyceride that has an 18-carbon fatty acid attached to it by Ester bonds. You will have to degrade the glycerol component followed by the fatty acid in presence of O2.
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