Reference no: EM13923254
A. Successful HCV treatment also called sustained virology response (SVR) is defined as a patient's viral load below the lower limit of quantification at a follow-up evaluation at 24 weeks after the completion of the treatment. On the other hand, patients who do not attain SVR, the viral load either rebounds to pretreatment levels during the therapy (partial virology response (PVR) or breakthrough (undetectable viral load followed by increase during treatment)) or returns to pretreatment levels upon cessation of therapy (relapse). Consider the following mathematical model for HCV viral kinetic with interferon-α therapy () that was discussed in class: dT dt = s - dT -
βV T dI dt = βV T - δI dV dt = (1 - )pI - cV.
1. Implement the above model in SimBiology with the initial conditions T(0) = 1.4984e+06, I(0) = 0.4724e + 06, V (0) = 4.3881e + 06 and parameter values β = 4.1684e - 09, δ = 0.1211, p = 25.1, c = 2.7018, = 0.61382, s = 61.7e + 3, d = 0.003. Simulate the solutions for 336 days and describe the results. Is the treatment successful?
2. Repeat part 1. with the initial conditions T(0) = 0.9167e + 06, I(0) = 0.1009e + 06, V (0) = 5.3591e + 06 and parameter values β = 1.2e - 08, δ = 0.58411, p = 25.1, c = 0.47268, = 1.0, s = 61.7e + 3, d = 0.003.
B. Write a summary (one to two page) of this module.
Write an expression that represents cost of admission prices
: Write an expression that represents the cost of the admission prices and the concession stand items based on the available information. Letdrepresent the cost for a large drink and letprepresent the cost of the popcorn.
|
Businesses in terms of employment law
: Why are small businesses treated differently than large businesses in terms of employment law?
|
Explanation of complexity theory
: Post an explanation of complexity theory that is applicable to the leadership and management of organizations. Provide a specific example, either from your own experience or from your readings, to support your explanation
|
Npv-sensitivity-risk-bias-ethics in capital budgeting
: Investment projects should never be selected through purely mechanical processes. Managers should ask questions about the positive net present value (NPV).
|
Implement the model sustained virology response
: A. Successful HCV treatment also called sustained virology response (SVR) is defined as a patient's viral load below the lower limit of quantification at a follow-up evaluation at 24 weeks after the completion of the treatment.
|
Calculate the required rate of return for mercury
: Calculate the required rate of return for Mercury, Inc., assuming that (1) investors expect a 4.0% rate of inflation in the future, (2) the real risk-free rate is 3.0%, (3) the market risk premium is 5.0%, (4) Mercury has a beta of 1.00, and (5) i..
|
Plan to apply procurement management
: Discuss Ways you Plan to Apply Procurement Management, What areas of monitoring and controlling a project seemed most challenging to you
|
What role did itunes play in apples corporate strategies
: What role did iTunes play in Apple's corporate strategies? What should Apple Inc. be doing to make its market leadership last (continue) given the fact of its history concerning a boom-and -bust performance.
|
Develop a decision table for this decision
: The annual returns will depend on both the size of the station and a number of marketing factors related to oil industry and demand for gasoline. After careful analysis, Susan developed the following table: 1. Develop a decision table for this ..
|