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The flipping of Phe rings requires that groups surrounding the ring move aside momentarily. The rate of ring flipping can be measured using NMR. You are studying two mutant versions of a protein. In both of the mutants, the proteins have considerable secondary structure, based on circular dichroism studies, and bind the hydrophobic dye ANS, indicating the formation of the hydrophobic core of the protein. However, in one of the mutants (mutant A), the rate of Phe ring flipping is much higher than in the other (mutant B). A researcher suggests that one of these mutants completes the folding process to form a misfolded protein, much like a prion, whereas the other is stuck at some point on the folding pathway.
A. Which mutant forms a misfolded structure? Explain your reasoning.
B. Where along the folding pathway is the other mutant stuck? Again, explain your reasoning.
At the starting of the spring, Dr. Betty Burner notices that there is an equal distribution of long and short-stemmed dandelions in her backyard.
The table presents the rates of reaction at specific substrate concentrations for an enzyme that displays classical Michaelis-Menten kinetics. Two sets of inhibitor data are also included.
Assume you work in a cool professor's Drosophila lab and you are told to figure a genetics problem regarding fly hairness.
Huntington disease is an autosomal dominant trait that causes neurodegeneration later in life. Matt, who is too young to show the phenotype of Huntington disease,
Utilize your imagination to describe two ways in which disturbance of the sort just described may affect the animals that live on the panels and amount of free space available.
What is the number of progeny expected in 1000
In Drosophila the genes for wing size and bristle length phenotypes long or short are inherited independently.
The standard reduction potential (Eo') for the reduction of fumarate is +0.03V. The Eo' for the reduction of FAD in a given protein that accepts the electrons from succinate is -0.40V. Given the reaction.
Suppose a protein of interest is known to bind the mitochondria to the ER. Suppose these proteins are small enough to fit into the vesicles and transfer to Goldgi apparatus.
Illustrate the structures of the sun including the interior, surface and atmosphere and what type of science is done to come to these conclusions. How does the structure of the sun compare to structure of the earth.
Imagine looking during a microscope at a squashed onion root tip. The chromosomes of many of cells are plainly visible. In some cells, replicated chromosomes are aligned along center (equator) of the cell. These particular cells are in which stage of..
Assume if a person has a kidney transport maximum for glucose of 150 mg/min, a glomerular filtration rate of 100 mL/min, a plasma glucose level of 250 mg/100 mL,
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