Zoonoses disease-transmissible spongif orm encephalopathies, Biology

Transmissible spongif orm encephalopathies


Transmissible spongiform encephalopathies (TSEs, also called Prion diseases) are fatal neurodegenerative diseases such as scrapie of sheep, Creutzfeldt-Jakob disease (CJD) of humans, bovine spongiform encephalopathy (mad cow disease) and chronic wasting disease (CWD) of deer and elk. Bovine Spongiform Encephalopathy is thought to be the cause of variant Creutzfeldt Jakob Disease (vCJD) which is a neurological disease different from CJD, leading to death in humans. TSEs are caused by accumulation of prion protein, an abnormal form of protein found in humans and animals. Normal prion protein is expressed in a wide variety of tissues, but conversion of normal prion protein to the TSE form appears to be restricted primarily to cells of the nervous and lymphoid systems. In order to determine why some cell types are more resistant to TSE infection than others, scientists developed a tissue culture system that allows them to monitor both acute and persistent abnormal prion protein (PrP- res) formation. It has been demonstrated that while any cell type can make new PrP- res following exposure to TSE infectivity, only some cell types go on to become chronically infected and make PrP-res persistently. This suggests that there are cell- specific factors that determine the susceptibility of a cell to chronic TSE infection. These factors, once identified, could be useful in designing effective anti-TSE therapeutics.

Posted Date: 9/20/2012 2:11:02 AM | Location : United States







Related Discussions:- Zoonoses disease-transmissible spongif orm encephalopathies, Assignment Help, Ask Question on Zoonoses disease-transmissible spongif orm encephalopathies, Get Answer, Expert's Help, Zoonoses disease-transmissible spongif orm encephalopathies Discussions

Write discussion on Zoonoses disease-transmissible spongif orm encephalopathies
Your posts are moderated
Related Questions

Temperature - Aquatic Habitats The water temperature changes less rapidly than the temperature of air because water has a considerably higher specific heat than air, that is l

How potassium is essential for the following physiological functions It is vital for photosynthesis. When K + ion is deficient, photosynthesis declines and respiration incr

Membrane-bound organelles are absent in : 1. Saccharomyces 2. Streptococcus 3. Chlamydomonas 4. Plasmodium Streptococcus

Which is the autotrophic group responsible for the production of most part of the molecular oxygen of earth? Cyanobacteria and Algae of the phytoplankton are the organisms that

What are the genes responsible for the toxic substance in bt?

Explain the Periapical surgery - Endodontic Surgery a) Curretage 1 b) Root-end ressection 2 c) Root-end preparation 3 d) Root-end filling 4

Discuss the biological importance of Imidazole. Bring in examples of biomolecules that contain this group. Please be as thorough as possible.

State what is Genetic engineering Genetically engineered plant-incorporated protectants are created by a process that utilizes  several dissimilar modern scientific techniques

What is agar-agar? Agar-agar is a sulphonated mucopolysaccharide containing mainly D-galactose, D-glucuronic acid and 3,6 anhydro L-galactose. It is derived from red sea weed e