Somatic and germline gene therapy, Biology

All the cells present in the body contain genes and an approach targeted to modulate the expression of genes is known as gene therapy. This novel approach has emerged by the end of 20th century and comes up with a promise of treating a large number of genetic disorders by ultimately modifying the gene expression (Jin et al, 2008). The two forms of gene therapy are somatic and germ line.

Somatic gene therapy: During this therapeutic approach, the genetic diseases are treated by inserting recombinant genes into non-reproductive or somatic cells. This kind of approach is limited to the patient and does not get transmitted to the future generations of. A normal copy of the malfunctioning gene is inserted into the mutant cells due to which an improvement in the disease phenotype is observed (Dorin, 1996). In the recent past, this technique has been found to be successful in case of familial hypercholesterolaemia and adenosine deaminase deficiency. For treating these disorders hepatocytes and T cells have been used for gene transfer respectively (Dorin, 1996). It has also shown significant success in case of cystic fibrosis and cancer. Various vehicles, like viral and non viral vectors help in the introduction of the genetic material into the mutated cells (Elias and Annas, N.D). This therapeutic approach is categorized into three sections:

  • ex vivo - The genetic engineering of the cell is done outside the body and finally the cells are returned to the body. (Ex: blood cells)
  • in situ - The cells of the affected tissues are directly transfected with vectors carrying genetic material. (Ex. Tissues of the respiratory tract)
  • in vivo - The vector is directly injected into the blood stream and this method is still in the developmental stages (Anderson, N.D).

However this approach produces short term results as the tissues die and get replaced with other cells.

Posted Date: 8/9/2012 6:32:53 AM | Location : United States







Related Discussions:- Somatic and germline gene therapy, Assignment Help, Ask Question on Somatic and germline gene therapy, Get Answer, Expert's Help, Somatic and germline gene therapy Discussions

Write discussion on Somatic and germline gene therapy
Your posts are moderated
Related Questions
Explain briefly about the selenium Toxicity? There is a narrow margin between the beneficial and harmful intakes of selenium. The level at which selenosis occurs is not well-de

what are the uses of computer in biotechnology ??? briefly explain any twenty

Neural Basis of Responses to Sex Pheromones The ability of insects to detect and discriminate between a variety of pheromones with great sensitivity depends on the presence of

Determine about the Secondary minerals Secondary minerals are formed under conditions of temperature and pressure found at theĀ  Earth's surface by the weathering of pre-existi


Explain the Urinary System in human body? The urinary system removes the waste materials produced as a result of all the metabolic process required to sustain life. The process

Define about the Sporocyst Larva? Sporocyst is the second larval stage in the life cycle of F. hepatica. It develops from the miracidium larva within the pulmonary chamber of

How do you explain in the absence of aldehyde group in the pentaacetate of D-glucose? Ans) when you react glucose with acetic anhydrate it forms pentaacetate with 5 OH grops it tel

Dietary management during Myocardial Infarction? Patients who suffer from an attack of myocardial infarction are hospitalized and are usually kept under strict medical supervis

Explain the Principle or Theory of biuret method? If a strongly alkaline solution of Biuret is heated with very dilute copper sulphate, a violet colour is obtained. The substan