Somatic and germline gene therapy, Biology

All the cells present in the body contain genes and an approach targeted to modulate the expression of genes is known as gene therapy. This novel approach has emerged by the end of 20th century and comes up with a promise of treating a large number of genetic disorders by ultimately modifying the gene expression (Jin et al, 2008). The two forms of gene therapy are somatic and germ line.

Somatic gene therapy: During this therapeutic approach, the genetic diseases are treated by inserting recombinant genes into non-reproductive or somatic cells. This kind of approach is limited to the patient and does not get transmitted to the future generations of. A normal copy of the malfunctioning gene is inserted into the mutant cells due to which an improvement in the disease phenotype is observed (Dorin, 1996). In the recent past, this technique has been found to be successful in case of familial hypercholesterolaemia and adenosine deaminase deficiency. For treating these disorders hepatocytes and T cells have been used for gene transfer respectively (Dorin, 1996). It has also shown significant success in case of cystic fibrosis and cancer. Various vehicles, like viral and non viral vectors help in the introduction of the genetic material into the mutated cells (Elias and Annas, N.D). This therapeutic approach is categorized into three sections:

  • ex vivo - The genetic engineering of the cell is done outside the body and finally the cells are returned to the body. (Ex: blood cells)
  • in situ - The cells of the affected tissues are directly transfected with vectors carrying genetic material. (Ex. Tissues of the respiratory tract)
  • in vivo - The vector is directly injected into the blood stream and this method is still in the developmental stages (Anderson, N.D).

However this approach produces short term results as the tissues die and get replaced with other cells.

Posted Date: 8/9/2012 6:32:53 AM | Location : United States







Related Discussions:- Somatic and germline gene therapy, Assignment Help, Ask Question on Somatic and germline gene therapy, Get Answer, Expert's Help, Somatic and germline gene therapy Discussions

Write discussion on Somatic and germline gene therapy
Your posts are moderated
Related Questions
Hypomagnesaemic tetany of calves Young calves in the age group of 2-8 weeks and fed whole milk or milk replacer are more likely to develop hypomagnesaemia due to inadequate ma

A decrease in blood plasma levels of parathyroid hormone A. occurs in response to an increase in the levels of calcium ions in blood plasma. B. leads to an increase in the a

PAEDIATRIC NURSING   Parent education, family health promotion and health maintenance have been the concern of yesterday's and today's nurses. Florence Nightingale over a hu

Q. Type specimen of class enteropneusta? Examine the specimen and note the following features: 1. Balanoglossus has a soft, elongated, worm-like body which has a ciliated surf

Implementation The planned goals and strategies are translated into nursing intervention by means of the nursing care plan. It is essential that the client and family par

Discuss the similarities and differences of transposable elements in E. coli, yeast, plants, and Drosophila.

Explain Lyme disease The disease - About 70-80% of patients infected by B. burgdorferi develop the characteristic skin lesion, erythema migrans, which occurs at the site of the

Q. Under which conditions do aerobic cells carry out fermentation? Some cells that usually obtain energy from aerobic cellular respiration can perform fermentation when oxygen

Q. What is the vena cava? Which type of blood circulates within the vena cava? The vena cava is either of two large veins that debouch into the right atrium the superior vena c

Classification of Colloidal Systems Thomas Graham referred to colloids as  the study of sub microscope dispersion. According to him, it dealt with the dispersed systems of a de