Scrapie, Biology

Scrapie

This is a chronic fatal disease of sheep and occasionally of goats caused by a Prion agent similar to BSE. The disease is reported from Europe, North America and in a few countries of Africa and Asia.

Clinical signs: Incubation period is of 2-5 years. Affected sheep show excitement, signs of muscular tremors of head and neck, wavering gait, vacant look and paraplegia. Sheep develop pruritus with wool loss and skin rubbed raw. They loose weight and ultimately die.

Diagnosis: The disease is diagnosed by the clinical signs, direct electron microscopy of brain material or demonstration of Prion protein by Western blot. The agent can be transmitted to mice and hamster and these species are being used as laboratory models for characterizing the agent.


Prevention and control:
The disease is controlled by systematic detection of infected  and in-contact animals and their disposal by slaughter and consequently building disease free "certified flocks".

Posted Date: 9/18/2012 7:13:22 AM | Location : United States







Related Discussions:- Scrapie, Assignment Help, Ask Question on Scrapie, Get Answer, Expert's Help, Scrapie Discussions

Write discussion on Scrapie
Your posts are moderated
Related Questions
Define about the Chemotherapy - Cancer? Chemotherapy results in lot of side effects. This is because the drug effects are not specific to cancer cells alone. Even the host cell

Nitrate Uptake Nitrate must enter the cells before undergoing assimilatory reduction by the joint action of nitrate reductase and nitrite reductase. Cells accumulate NO - 3

Several living organisms exhibit the unique property of producing visible light. Compound that is oxidized with subsequent light emission is generally referred to as luciferin. Wha

The agouti locus in mice has three alleles: A is recessive and confers a black coat, A is dominant to a and confers an agouti coat, and AY is dominant to both and confers a yellow

Q. Which is the typical feature of the hookworms related to the way they obtain food and explore the host? Both The Necator americanus and Ancylostoma duodenale have mouthparts

Q. Describe Consciousness as the waking state? Consciousness as the waking state: consciousness is also referred to as the waking state as opposed for example to sleep. All

Ask Two true-breeding pea plants were crossed. One parent is round, terminal, violet, constricted, while the other expresses the respective contrasting phenotypes of wrinkled, axia

Secondary Prevention: The various aspects of  secondary prevention are:  1)  Early Diagnosis  and  Case Finding  This can be achieved by  educating the public and commun

Improper Implant type in Improper Bone Type In routine sites with good quality bone, the clinician should prefer implants without any superadded HA coatings and avoiding their

Which of the following is true for a G-protein? A. When an agonist binds to the binding site of a G-protein-coupled receptor (GPCR), this leads to GDP displacing a GTP bound to