Scrapie, Biology

Scrapie

This is a chronic fatal disease of sheep and occasionally of goats caused by a Prion agent similar to BSE. The disease is reported from Europe, North America and in a few countries of Africa and Asia.

Clinical signs: Incubation period is of 2-5 years. Affected sheep show excitement, signs of muscular tremors of head and neck, wavering gait, vacant look and paraplegia. Sheep develop pruritus with wool loss and skin rubbed raw. They loose weight and ultimately die.

Diagnosis: The disease is diagnosed by the clinical signs, direct electron microscopy of brain material or demonstration of Prion protein by Western blot. The agent can be transmitted to mice and hamster and these species are being used as laboratory models for characterizing the agent.


Prevention and control:
The disease is controlled by systematic detection of infected  and in-contact animals and their disposal by slaughter and consequently building disease free "certified flocks".

Posted Date: 9/18/2012 7:13:22 AM | Location : United States







Related Discussions:- Scrapie, Assignment Help, Ask Question on Scrapie, Get Answer, Expert's Help, Scrapie Discussions

Write discussion on Scrapie
Your posts are moderated
Related Questions
Pericardiocentesis It is removal of fluid form the pericardial sac. It is a specialized procedure done n ICU or cardiac cath lab or OT. A 16 or 18 gauge needle is inserted

Determine the food sources of riboflavin? The food sources of riboflavin include: 1. Rich sources: Liver, dried yeast, egg powder, milk powder. 2. Good sources: Who

Carboxypeptidase The  inactive  zymogen  procarboxypeptidase  is  activated  by  trypsin .The further action on the polypeptides is carried out by carboxypeptidase which  attac

Patients with aborted sudden death, hemodynamically unstable ventricular arrhythmias, and unexplained cardiogenic syncope are at high risk for fatal ventricular arrhythmias. If the

What are the effects of acid precipitation on ecosystems?

Drosophila has 4 bivalents (homologous chromosomes) formed at Meiosis I. How many chromosomes and chromatin strands are present in each of the following stages- Anaphase of mito

Cell membrane lining the inner surface of the cell wall The cell membrane lining the inner surface of the cell wall is made up of phospholipids (45%) and proteins (55%). Some

Define Energy Expenditure in Hot Environments? Energy expenditure in hot environments is increased by a small but significant amount because of additional work of ventilation a

Hypotension, hyperkalemia, taste disturbance, angiedema, renal insufficiency. In the absence of any symptoms of hypotension, and normal renal function and K + levels, the dosage

Explain the Torsional Failure - Root Canal Test a. Occurs when the tip of the rotating instrument blinds (locked) in the canal while the motor continues to rotate the shank of