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Mechanistic data might be supplemented by data from in-vitro studies, like as information on genotoxicity derived from reversion assays or other same assays. These studies should be conducted following GLP and other widely accepted protocols. Though, data from in-vitro studies should not be used as the sole source of information to predict the human risk.
- The results of in-vitro studies can enhance the understanding of mechanisms and phannacokinetics/dynamics. Though, such information may not be available in many cases and the risk assessment process should not be delayed pending development of mechanistic and pharmacokineticldynamic data.
Is it possible to perform investigation of natural paternity, maternity or brotherhood and sisterhood using the ABO blood typing? By using the ABO blood typing it is possible o
What is Cilia and Flagella? The surfaces of many eukaryotic cells bear cilia or flagella, built from specialized microtubules. Cilia are tiny brushlike hairs, and flagella are
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Why TPP and TTP are vital for the nerves and cardiac tissues? TPP and TTP are interconvertible and arc involved in carbohydrate metabolism. As discussed above, when there is in
A hollow restoration may be fabricated based on the original form determined by the diagnostic preview. This restoration can be re-lined on completion of the surgical phase of impl
How Primarily Energy Deficiency cause PEM? Surveys on preschool children in different parts of the country reveal that PEM is primarily due to dietary energy deficiency arising
Which of the following is true for a G-protein? A. When an agonist binds to the binding site of a G-protein-coupled receptor (GPCR), this leads to GDP displacing a GTP bound to
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What is the type of reproduction that occurs in roundworms? What typical element do nematode sperm cells have? Nematodes reproduce sexually. The nematode sperm cell does not h
Chancroid Chancroid, caused by Haemophilus ducreyi, is rare in the US. A single dose of azithromycin or ceftriaxone is usually effective, but may be less effective in HIV-inf
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