Quaternary structure of protein, Biology

Quaternary Structure (4^o Structure).

Globular in structure.
When two or more than two molecules of protein of tertiary structure are connected to each other through various bonds then this structure is called quaternary structure.
Most stable protein.
Haemoglobin has 4 polypeptide chains (2 a chains & 2 b chains).
Insulin consists of 2 polypeptide chains (1 a chain & 1 b chain).
A chain of insulin consists of 21 amino acids and b chain insulin consists 30 amino acids.
Total numbers of 51 amino acids are present in insulin
Molecular structure of insulin described by F. Sanger (He got 1st time Nobel Prize)
He got 2nd time Nobel Prize for preparing chromosomal maps.

1328_quaternary structure.png

Quaternary structure was first studied in case of haemoglobin by Kendrew and Perutz (1963).

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