Promotion - stages of carcinogenesis, Biology

Promotion - Stages of carcinogenesis

The second stage or promotion is reversible and does not include changes in structure of DNA but rather in the expression of the genome of the initiated cell. This results from an interaction among the changed DNA structure and some environmental factors termed 'promoting agents'. The stage of promotion needs extended interaction with the promoting agent, if the third stage of progression is to be teached. Figure describes the process of promotion in a simplified way. A single application of an initiator to the skin of a mouse produces initiated cells but no tumor

1743_Promotion.png

Figure:  The concept of initiation and promotion 

(a) However, if the initiator is applied to the skin first then subsequent application of the promoter results in tumor

(b) If the promoter is withdrawn the tumor regresses leaving behind initiated cells and continued application of promoter on tumor bearing skin lends to invasive carcinoma.

(c) The application of a promoter alone to the skin also does not produce tumor

(d) If the promoter is applied before the initiator is applied even then no tumor is formed.

Posted Date: 1/31/2013 7:48:18 AM | Location : United States







Related Discussions:- Promotion - stages of carcinogenesis, Assignment Help, Ask Question on Promotion - stages of carcinogenesis, Get Answer, Expert's Help, Promotion - stages of carcinogenesis Discussions

Write discussion on Promotion - stages of carcinogenesis
Your posts are moderated
Related Questions
Define Role of Nutrients in Controlling Gene Expression? The role of several nutrients in controlling gene expression, as mentioned earlier, is in infancy, but with advancing b

Q. Do the membranes form only the outer wrapping of cells? Lipid membranes do not form only the outer cover of cells. Cell organelles, such as the Golgi complex, lysosomes, chl

Define Nutritional Requirements of Fats and Oils for Adults? A desirable amount of a linoleic acid to be consumed by a normal adult is 3 en% (ICMR, 1990). The invisible fat pre

Erythema migrans Oral antibiotic therapy shortens the duration of the rash and generally prevents development of late sequelae. Among the 3 drugs used for this indication, onl

Organisational Behaviour of Health Care The insights provided by the theories of organisational behaviour emphasise the need for the establishment of institutional frameworks

Tubercular Meningitis (TBM) Tubercular meningitis is a serious complication of childhood tuberculosis. It usually occurs secondarily to primary infection with tuburculosi

How do cells obtain energy for their functioning? Cells obtain energy for their metabolic reactions from the breaking of organic molecules with high energetic content. This ene

Q. How is the depolarization of the neuronal plasma membrane generated? How does the cell return to its original rest? When the neuron receives a stimulus by the permeability o

What are the functions of insulin and glucagon for the blood glucose control? Glucagon enhances glycemia and insulin reduces it. They are antagonistic pancreatic hormones. Gluc

Define Treatment and Management of Adverse Food Reactions? Management of adverse food reactions involves diagnosing the problem followed by nutritional and medical care.