Promotion - stages of carcinogenesis, Biology

Promotion - Stages of carcinogenesis

The second stage or promotion is reversible and does not include changes in structure of DNA but rather in the expression of the genome of the initiated cell. This results from an interaction among the changed DNA structure and some environmental factors termed 'promoting agents'. The stage of promotion needs extended interaction with the promoting agent, if the third stage of progression is to be teached. Figure describes the process of promotion in a simplified way. A single application of an initiator to the skin of a mouse produces initiated cells but no tumor

1743_Promotion.png

Figure:  The concept of initiation and promotion 

(a) However, if the initiator is applied to the skin first then subsequent application of the promoter results in tumor

(b) If the promoter is withdrawn the tumor regresses leaving behind initiated cells and continued application of promoter on tumor bearing skin lends to invasive carcinoma.

(c) The application of a promoter alone to the skin also does not produce tumor

(d) If the promoter is applied before the initiator is applied even then no tumor is formed.

Posted Date: 1/31/2013 7:48:18 AM | Location : United States







Related Discussions:- Promotion - stages of carcinogenesis, Assignment Help, Ask Question on Promotion - stages of carcinogenesis, Get Answer, Expert's Help, Promotion - stages of carcinogenesis Discussions

Write discussion on Promotion - stages of carcinogenesis
Your posts are moderated
Related Questions
uses and advantages and disadvantages of immunolocalization

Careful palpation of the upper and lower limb pulses would make one suspect coarctation as the cause of hypertension. The lower limb pulses are weak and delayed. Confirmation ca

Fluoxetine is an antidepressant drug that presents an action mechanism related to the synaptic transmission. What is that mechanism? Fluoxetine is a substance that inhibits th

Where does poop come from?

Q. How different are pteridophytes from bryophytes regarding substance transport? Pteridophytes are tracheophyte (vascular) plants that are they have tissues specialized in con

what two gases are released by animals during the process of cellular respiration

Illustrates about the effect of wall movement on earth pressure? Effect of wall movement on earth pressure About fifty years ago Terzaghi conducted a series of tests on larg

Meat products Meat is an important commodity in the diet of people in view of its complimentary role in balancing the diet with rich source of amino acids, vitamins and mineral

Explain what is tooth formula? Ans) Formulae of tooth is (2, 1, 3, 2)

Pollinia and Massulae In most cases the pollen grains of each tetrad become separated from one another and they lie freely in the pollen sac. In some plants, mostly members of