Physiology of respiration, Biology

PHYSIOLOGY OF RESPIRATION -

1.      EXCHANGE OF GASES -

  • It is Haemotasis. It takes place in Alveoli between alveolar air and arterial cappilary by diffusion i.e., from high partial pressure to low partial pressure.
  • O2   104 →  40 mmHg
  • CO2  46 → 40 mmHg

2.      TRANSPORTATION OF O2  BY BLOOD -

  • O2 is less soluble so 3% O2 is transported by plasma. 97% O2 is transported by Hb.
  • 1 Hb can carry 4 O2 .
  • If Hb reacts with O3   or any other oxydising agent Methemoglobin is formed. Now it cannot carry O2 .
  • Reaction of Hb with O  is oxygenation not oxidation. Because e- are not given out.
  • Hb4  + 4O2  → Hb4 O8
  • O2   reaches to every cell in the form of oxyhaemoglobine. In cell dissociation of Hb.O2   occur.
  • Hb.O2 →  Hb + O2

2462_transportation of oxyen.png   1759_transportation of oxygen.png

  • Partial pressure of Ois less in cell.
  • If CO2   concentration is more, then dissociation curve bends to right. It is Kristan's Bohr effect.
  • This curve is Sigmoid not similar in all animals. It is normal at 40 mm Hg CO2 . Shown by winton & Begllis.

3.      INTERNAL RESPIRATION -

Internal respiration occur in cell. It includes glycolysis and Kreb's cycle


4
.      TRANSPORTATION OF CO -

  • CO2   is more soluble than O2. So from cell it comes in extra cellular fluid and then in blood.
  • CO2   is transported in 3 forms.

(a)           In the form of physical solution: 7%

H2O +CO2 → H2CO3

If complete CO2   is transported in this form pH of blood will come to 4.5.

(b)            As chemical compound: 23%

CO2  +Hb.NH2  → Hb.NH.COOH

Carbomino haemoglobine

(c)           As bicarbonates - 70%

998_transportation of carbon dioxide.png

  • Mostly CO2   is diffused from plasma to RBC.
  • Here H2CO3  is formed 5000 times faster in the presence of carbonic anhydrase enzyme.
  • H2CO3 is broken into H+ and HCO- .
  • H+ combine with Hb to from HbH+ (strong buffer).
  • HCO3-  is diffused out in plasma balanced by Cl ion i.e., chloride shifting or Hemberger phenomenon.
  • In plasma HCO- reacts with Naor K+ to form their bicarbonates.
  • 4 ml CO2   is transported by 100 ml blood.
  • According to Henderson Hesselwalch at 7.4 pH ratio betwen H2CO3  and bicarbonate is 1 : 20.

5.      RELEASE OF CO2  AT RESPIRATORY SURFACE-

As more and more oxyhaemoglobine is formed more COis released. So reaction against oxygenation is Haldane effect.

HbH+ →Hb + H+

Hb +O2 →Hb.O2

H+ +HCO→ H2CO3

H2CO3  → H2O +CO2

6.      CONTROL ON RESPIRATION-

  1. It is automatic involuntary process negligible voluntary too.
  2. Medulla oblongeta is respiratory centre. Effected by chemicals in blood.
  3. It is bilateral. Half part is inspiratory and half part is expiratory.
  4. ICM nerve (ICM) and phrenic nerve (Diaphragm) stimulate inspiration.
  5. Streach receptors in Bronchi & Bronchioles are stimulated. It is conveyed to brain by vagus nerve.
  6. Inspiration is stoped. Expiration is started. This feed-back control is Hering Breuer Reflex.
  7. More CO2  increases rate of respiration.
  8. CO poisoning: Hb combines with CO 250 times faster. So carboxyhaemoglobine is formed.
Posted Date: 10/1/2012 9:14:31 AM | Location : United States







Related Discussions:- Physiology of respiration, Assignment Help, Ask Question on Physiology of respiration, Get Answer, Expert's Help, Physiology of respiration Discussions

Write discussion on Physiology of respiration
Your posts are moderated
Related Questions
If I take a drug that induced the synthesis of CYP 2E1 in my system, would that raise or lower my blood alcohol level after I drink a beer or wine (compared to if I hadn''t taken t


Explain Materials for Root End Filling- Amalgam a) Its radiopacity is the better than any other REF materials b) Greatest amount of leakage! c) Corrosion, and significant

Explain Electron transport chain Electron transport chain :Transport of high-energy electrons through a series of carriers in mitochondria.

What Devices Used for Oxygen Therapy? Variable performance systems: With these devices, the FiO 2 would vary depending on the patient's breathing pattern. In general, rapid, s

define stds give 5 examples of stds give signs, symptoms, treatment and prevention of each example

Q. Medical therapy for tricuspid stenosis? Medical therapy is ineffective. With diuretics, symptoms of congestion are replaced by that of low cardiac output state. Occasional c

Q. Etiologic factor of diabetes? The precise etiology of diabetes is not known but multiple factors contribute to the disorder. These are reviewed herewith. Type I Diabetes

Define the meaning of value - Soil Value refers to relative lightness or darkness of a colour and is a measure of the amount of light that reaches the eye under standard lighti

Assuming independent assortment, what proportion of the offspring of the cross AaBbCcDd × AabbCCdd will have the aabbccdd genotype?