Physiology-based pharmaco-kinetic (pbpk) models, Science

Answer the following questions:

(a) What are the objectives of the Bischoff PBPK model? What useful predictions is the model capable of making? How is the model able to translate results from mice to humans?

(b) What are the simplifying assumptions of the model? Why are some organs included in the model while others are excluded? What additional organs would you include for an antidepressant drug? What organs would you include for the drug Lithium (which is used for the treatment of pregnant bipolar women, see paper on by Horton - Tuerk-Cook-Dhur jati)

(c) Verify the mass balance equations for the kidney compartment in the Bischoff model? Explain the physiological meaning of each variable and parameter in the equation.

(d) Run the matlab files provided to you (file sent) and confirm the predictions of the Bischoff model for all organs. Two sets of matlab code are provided, one by a former TA and one that is more structured. Solve the model for the parameters provided for different animals and for the drug, methotrexate (a chemotherapeutic agent). How would you interpret the simulated concentration profiles in terms of physiology? What experiments would you perform to validate the concentration of methotrexate as a function of time for all organs in the model?

 

Posted Date: 2/15/2013 4:31:12 AM | Location : United States







Related Discussions:- Physiology-based pharmaco-kinetic (pbpk) models, Assignment Help, Ask Question on Physiology-based pharmaco-kinetic (pbpk) models, Get Answer, Expert's Help, Physiology-based pharmaco-kinetic (pbpk) models Discussions

Write discussion on Physiology-based pharmaco-kinetic (pbpk) models
Your posts are moderated
Related Questions
Explain the Ketone bodies -  abnormal constituent of urine Ketone body is an intermediate breakdown product of fats in the body. It can be any of three compounds (acetoacetic a

Intrusion into the Carbon Cycle   In  the carbon cycle, as long as the average amount of carbon dioxide hair and in water remains the same, a happy situation prevails. If the te


Explain the Lubrication of food Dry food enters the mouth. It is moistened and lubricated by the saliva, before it can be made into a bolus ready for swallowing.

Determine in detail about the Phosphorus  Phosphorus, with nitrogen and potassium is classed as a major nutrient element. It is a constituent of nucleic acids, phytin, phosphol

# Fråga ..



Explain Betice Jones Protein - abnormal constituent of urine Betice-Jones Protein: Bence-Jones proteins are the small proteins (dimers of iminunoglobuljn light chains) normally

I want to know about moodle ..