Phosphorylation of glucose, Biology

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Phosphorylation of  glucose

Glucose is converted to  glucose-6-phosphate since phosphorylated  intermediates do not readily penetrate cell membrane and  this commits glucose  to  further metabolism  in  the  cell. Hexokinase catalyses  this irreversible reaction  in most tissues and in  liver; glucokinase  is the predominant enzyme for the phosphorylation of glucose. Hexolcinase is an allosteric enzyme that is strongly inhibited by the product glucosed-phosphate.

 


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