Pbpk models strategies, Strategic Management

Model-Building Strategies

Various strategies have been used when implementing whole body PBPK models. As discussed below, it is important to distinguish between model building for simulation from that for data analysis. In the latter case, parameter identifiability is a crucial element of the process. Debates on model structure are ongoing between the "complicators" (ie, those wishing to retain as much of the higher level structure of the global model as possible) and the "KISsers" (those wishing to "keep it [the model] as simple as possible," through lumping of various tissues together). Whatever the case, the modeling process and, implicitly the complexity of the model it- self, are best undertaken with an eye to the intended application. In practice, this may vary during drug discovery and development as more data become available (such as tissue levels obtained during safety assessment); hence, it is very important to be flexible in the approach. Moreover, if model reduction is employed, it should be undertaken in a formal and systematic way-rather than in the arbitrary manner so commonly seen-and it should allow for model expansion, if subsequently needed.

A parallel activity has been the development of models to describe the performance of individual organs and tissues of the body. In its simplest and commonly ap-plied form, each tissue is regarded as a well-stirred sys-tem, yet experimental data sometimes point to the need for more realistic yet more complex models that take into account such factors as the various physical spaces within tissues, the existence of permeability barriers, organ heterogeneity, and active transport or metabolic processes.

Posted Date: 2/19/2013 12:04:07 AM | Location : United States







Related Discussions:- Pbpk models strategies, Assignment Help, Ask Question on Pbpk models strategies, Get Answer, Expert's Help, Pbpk models strategies Discussions

Write discussion on Pbpk models strategies
Your posts are moderated
Related Questions
Times it consists concerned with the determination of the amount of time required to perform a unit of work. It consists of process of observing and recording the tim

Strategies of the organisation support in the business expansion and increase the revenue . Following are the strategic capabilities: Production: Open kitchen system is used by

Q. Factors about transfer pricing? Does the supplier have a solid track record for delivery e.g. references from other satisfied customers in terms of the quality of servic

I have one real option problem I need help with

Ray's Satellite Emporium wishes to verify the best order size of their best selling satellite dish (model TS111).  Ray has estimated the yearly demand for this model at 1,000 units

I need a project and summary of Nano Manufacturing papers, please let me know how much cost it is? i need paper for my final year exam. I would like to finish my Nano Manufacturing

How has McLaren overcome the market entry barriers that are present in the mass car market?

What are Woo''s challenges in February 2011?

Protecting and strengthening the organization's position in its present markets by its current products