Pbpk models strategies, Strategic Management

Model-Building Strategies

Various strategies have been used when implementing whole body PBPK models. As discussed below, it is important to distinguish between model building for simulation from that for data analysis. In the latter case, parameter identifiability is a crucial element of the process. Debates on model structure are ongoing between the "complicators" (ie, those wishing to retain as much of the higher level structure of the global model as possible) and the "KISsers" (those wishing to "keep it [the model] as simple as possible," through lumping of various tissues together). Whatever the case, the modeling process and, implicitly the complexity of the model it- self, are best undertaken with an eye to the intended application. In practice, this may vary during drug discovery and development as more data become available (such as tissue levels obtained during safety assessment); hence, it is very important to be flexible in the approach. Moreover, if model reduction is employed, it should be undertaken in a formal and systematic way-rather than in the arbitrary manner so commonly seen-and it should allow for model expansion, if subsequently needed.

A parallel activity has been the development of models to describe the performance of individual organs and tissues of the body. In its simplest and commonly ap-plied form, each tissue is regarded as a well-stirred sys-tem, yet experimental data sometimes point to the need for more realistic yet more complex models that take into account such factors as the various physical spaces within tissues, the existence of permeability barriers, organ heterogeneity, and active transport or metabolic processes.

Posted Date: 2/19/2013 12:04:07 AM | Location : United States







Related Discussions:- Pbpk models strategies, Assignment Help, Ask Question on Pbpk models strategies, Get Answer, Expert's Help, Pbpk models strategies Discussions

Write discussion on Pbpk models strategies
Your posts are moderated
Related Questions
Write a submission to your chief executive officer of your organisation describing a strategy to improve the organisation's assets, their management, and the standard of service wh

explain strategy as an organisational process

1 .Characterize the culture of the organization in which you work. How does this culture affect the work of middle managers? Have you experienced deliberate interventions by senior

Q. What is Transfer Pricing? A transfer price is a price charged for goods or services provided internally between divisions or departments in the same group or company.   Tran

The assignment for the module is an individual report which contributes 25% of the module total mark. You should conduct a Strategic Position Analysis (Situation Analysis) on an or

Q. Evaluate Total shareholder return? Total shareholder return (TSR) TSR = {(Dividend per share + Growth in share price) / (Market share price at the start of the period)

Strategy formulation presupposes a set of goals and objectives. Why aren’t goals and objectives obvious? What characteristics of people and organizations can make setting goals and

Question: Strategy implementation can be said to consist of securing resources, organizing these resources and directing the use of these resources within and outside the organ

Q. Calculate the Price earnings ratio? Price earnings (PE) ratio PE   = (Market share price/EPS)                     (no. of times) The PE ratio is most widely quoted inv

Focused Factories - Limited Vertical Integration Japanese companies prefer specialisation (derived from Adam Smith's theories on division of labour), with a limited or focused