Pathophysiology and assessment of purpura, Biology

Pathophysiology 

Normally the platelets are formed from megakaryocytes (stem cells) in the.  bone marrow. These cells mature, fragment and are released in  the blood stream. In idiopathic thrombocytopenic purpura  there  is rapid platelet  destruction beacuse of presence of platelet antibodies which results  in bleeding. There is no  failure to produce platelets as there are abundant platelet precursors (megakaryocytes)  in the bone marrow. 

Assessment 

The child may present with petechiae ecchymosis, bleeding of the gums and epistaxis. Bleeding in  the skin may be seen prominently over the legs. There may be hematemesis, malena, haematuria and haemarthrosis which indicate  internal haemorrhage. There may also be occasional low grade fever. Anaemia may be present  if there  is significant  blood loss. Diagnostic evaluation includes laboratory examination of blood which reveals platelet  count below  (40,000) 20,000/mm3 other platelet function tests  such as tourniquet test, bleeding time and clot retraction is abnormal. The white blood cell count and cloting time  is normal. 

Posted Date: 10/27/2012 12:54:39 AM | Location : United States







Related Discussions:- Pathophysiology and assessment of purpura, Assignment Help, Ask Question on Pathophysiology and assessment of purpura, Get Answer, Expert's Help, Pathophysiology and assessment of purpura Discussions

Write discussion on Pathophysiology and assessment of purpura
Your posts are moderated
Related Questions
Explain the interaction of vitamin A with Iron? Iron: Iron status of an individual correlates with vitamin A. The deficiency of  vitamin A has been found to be associated with

Q. What is the function of the plant cell wall? The plant cell wall has protective and structural functions. It plays an significant role in the constraint of the cell size, pr

Explain the term - Migraine Perhaps the most common neurological disorder, migraine afflicts some 5% to 20% of the population at some time in their lives. The World Federation

What is Metabolism ?  The  sum total of vital activities ( movements , nutrition, growth, respiration, excretion , reproduction, behaviour ,etc.  Is the  life  of a living  bei

hi there,i would like u to help me with understanding Hutchinson phyletic dieta


Q. Do echinoderms have circulatory and respiratory systems? In echinoderms there are not well- defined respiratory with the exception of the holothurian group and circulatory s

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Q. Show the pH range of natural honey? The pH of natural honey ranges from 3.4 to 6.1. Acidity of honey is primarily due to presence of acids such as gluconic acid, pyruvic a

Diagrammatic representation of Implant placement Implant placementIt is located directly apical to the tooth it is replacing and not in an embrasure space. The angulati