Pathophysiology and assessment of patent ductus arteriosus, Biology

Pathophysiology 

If  the ductus arteriosus does not close after birth, the higher pressure in the aorta than in the pulmonary artery causes the blood to flow from the aorta, through the patent ductus into the pulmonary artery thus resulting in left to right shunt. This results in increased work load on the left side of  the heart, increased vascular pressure  in the pulmonary tree and increased blood flow in the ascending aorta. 

Assessment 

The clinical features depend upon the size of  the ductus and the amount of  shunting. The defect is discovered only on routine examination of  a classic "machinery murmur" which occurs during systole as well as diastole. 

The mild symptoms may include growth retardation, dyspnoea on exertion, palpitation, easy fatigability and recurrent  respiratory infection. Other clinical symptoms may include heart rate over 150/minute, gallop rhythm due to rapid filling of the ventricle, bounding pulses due to increased systolic pressure and wide pulse pressure. In severely affected cases congestive heart failure may  be present. 

Radiologic examination and electrocardiogram shows enlargement of  left ventricle and left atrium. The ascending aorta is dilated and there is increased pulmonary vascularity. Echocardiogram  is normal and the cardiac catheterization  if  necessary shows increased pressure in right ventricle and pulmonary artery and oxygenated blood in pulmonary artery.  

Posted Date: 10/26/2012 8:42:18 AM | Location : United States







Related Discussions:- Pathophysiology and assessment of patent ductus arteriosus, Assignment Help, Ask Question on Pathophysiology and assessment of patent ductus arteriosus, Get Answer, Expert's Help, Pathophysiology and assessment of patent ductus arteriosus Discussions

Write discussion on Pathophysiology and assessment of patent ductus arteriosus
Your posts are moderated
Related Questions
What happens to the movement of molecules at equilibrium? At equilibrium, the movement of molecules continues, but because there is no concentration gradient, there is no net m

What is circulation? Circulation is the movement of substances as nutrients and gases within blood vessels and cavities all by the organism.

Consider Neuron B in the frog central nervous system whose plasma membrane has a previously unknown channel that is selectively conductive to a newly discovered divalent cation nam

Topology and Cell Organ Shapes Topology is an abstract mathematical exercise that deals with the possible shapes and surfaces of an endlessly/infinitely elastic body. Most cel

A new drug named AGON-CaSR has been developed that is an agonist at calcium-binding sites of CaSRs (Calcium-Sensing Receptors) in plasma membranes of parathyroid gland cells.

Zymogens, or proenzymes, are enzymes secreted in inactive form. Under certain conditions, a zymogen shifts to the active form of the enzyme. Zymogen secretions in general occur due

What are the Properties of titanium Titanium has several favourable properties like low specific gravity with a density of 4.5 gm/cm 3 , high heat resistance and high strength

DNA Replication Deoxyribonucleic acid (DNA) is the carrier of genetic data for all living creatures. An organism's genome, made of DNA, encodes the genetic blueprint for buildi

phlum,class,characteristics of chromalveolata

At the present level of the biotechnology what are the main techniques of genetic engineering? The major techniques of genetic engineering today are: the recombinant DNA techno