Ovarian androgens, Biology

Ovarian Androgens

Androgens are masculinising compounds that are produced chiefly by the testis under normal conditions. They also arise from the adrenal cortex, ovaries and placenta. These are C-19 compounds derived from the basic structure androstane. Androsterone and testosterone are the principal androgens.

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Figure: Androsterone

Since testosterone is an intermediate in the biosynthesis of estrogens, therefore, this hormone may be present/secreted by the ovaries. The ovarian androgens exhibit the same biological activity as that of testicular androgens. Pathological ovaries may release tremendous amount of androgens, but the amount of androgens secreted by the normal ovaries is not significant.

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