Muromonab cd-3 , Biology

Muromonab CD-3 (Orthoclone, OKT-3)

A monoclonal antibody against mature T lymphocytes, OKT-3 is primarily used to treat acute rejection episode. IV for 10-14 days. Effect monitorcd by T lymphocytes count and by serum levels of OKT-3.

Adverse effect:

Chills, fever lasting upto one hour. Respiratory symptoms may occur and be life-threatening if the patient is fluid overloaded. Aseptic meningitis, infection with cytomegalo-virus or herpes simplex virus can occur.

Headache and flue-like symptoms may develop.

Most side-effects occur during the first two doses. To reduce some of the side- effects, the patient may be given methylprednisolone, acetaminopen and anti- histamine before OKT-3 is administered. Monitor the patient intensively for the
first two doses, vital every 15 minutes.

Signs and symptoms of acute rejection in heart transpIants patients Sjmptoms: fatigue, lethargy, dyspnea, decreased tolerance for exercise.

Signs:

fluid retention, peripheral edcma, jugular venous distention, crackles, pericardial friction rub, ECG changes-dysrhythmias and decreased voltage, decreased cardiac output, hypotension, cardiac enlargcrnent.

Identify the signs and sylnptoms and assist with treatment to improve the condition.

Endocardial biopsy is the major diagnostic test used to assess rejection. The patient showing signs of rejection may be treated with increasing doses of immunosuppressive agents. For prevention of infection specially pulmonary infection-hand washing, use of aseptic technique for all invasive procedures. Provide care that protects surface barriers form organism-mouth care after every meal, upon rising and at bed time, cleaning the skin folds by daily washing, lubricating and keeping moisture free.

Deep breathing exercises two hourly. Adequate nutrition, fluid intake. Avoid contact with the patient if care giver is with active infection.

Posted Date: 10/30/2012 9:00:13 AM | Location : United States







Related Discussions:- Muromonab cd-3 , Assignment Help, Ask Question on Muromonab cd-3 , Get Answer, Expert's Help, Muromonab cd-3 Discussions

Write discussion on Muromonab cd-3
Your posts are moderated
Related Questions
Enzymes utilization in food industry  Enzymes may be used in industry as components of living cells or after isolation in free or immobilized forms. All of them may be referred

Define Absorption, Storage and Elimination of Pyridoxine? Pyridoxine, pyridoxal and pyridoxamine (along with their phosphorylated forms) occur in plant and animal foods. The ph

Define Altered Glucose Metabolism - Nutrition during Stress? Blood glucose levels are generally elevated in the infected patient but plasma insulin levels are normal or even hi

Phylum-Bacteria (Eubacteria) Eubacteria,th e true bacteria, are extremely small and they exist in vast numbers virtually everywhere on earth. They range from the upper atmosphe

Explain Senning Procedure ? Operation is performed by ascending arteries and separate SVC and IVC cannulation. If the operation is done under deep hypothermic circulatory arres

Insulin binding to insulin receptors in the plasma membrane of a A. liver cell will lead to an enhance in the intracellular amounts of cAMP in the liver cell. B. beta-islet

Define Importance of Family and Patient Education - Food Allergy? Remember, involvement of the family and all other relevant caretakers along with the patient is crucial for pr

What is the approximate pH of the salivary secretion? Is it an acid or basic fluid? What are the main functions of saliva? The saliva pH is approximately 6.8. It is therefore a

Q. Explain Ciguatera Fish Poisoning? Ciguatera probably represents the most common cause of poisoning from fish in tropics. Ciguatera comprises over 50% of all reported case

Q. What are primary indications for pharmacologic stress? The primary indications for pharmacologic stress are inability to exercise or the desire to identify viable myocardium